Conserved Protein Domain Family
bHLH_TS_ATOH1

cd19713: bHLH_TS_ATOH1

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins

ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1).

Links

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Source:	cd11430
Taxonomy:	Gnathostomata
PubMed:	10 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl00081

Statistics

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PSSM-Id:	381556
Aligned:	7 rows
Threshold Bit Score:	112.738
Created:	28-Jun-2018
Updated:	2-Oct-2020

Structure

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Conserved Features/Sites?
PubMed References ?

putative DNAputative dimer

Feature 1:putative DNA binding site [nucleic acid binding site]

Evidence:

Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
Citation:PMID 8181063

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1              #   # ### #    #                 ####                     
Q92858       155 GVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFnNDKKLSKYETLQMAQIYINALSELLQTP 218 human
AAO59913       4 GVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFnNDKKLSKYETLQMAQIYISALAELLHGP 67  chicken
XP_018107642 106 GVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFnNDKKLSKYETLQMAQIYINALSDLLQAP 169 African clawed frog
XP_006010418 121 GVQKQRRLAANARERRRMHGLNHAFDQLRDVIPSFnNDKKLSKYETLQMAQIYINALAELLQSP 184 coelacanth
AAB82272     114 VVQKQRRMAANARERRRMHGLNHAFDELRSVIPAFdNDKKLSKYETLQMAQIYINALSDLLQGP 177 zebrafish
NP_001122151  89 GPQRHRRVAANARERRRMHGLNRAFDKLRSVIPSLeNEKKLSKYDTLQMAQIYITELSELLEGV 152 zebrafish
XP_007904461  48 PAPGRRRLAANARERRRMHGLNRAFDELRKVIPAL-EDKKLSKYETLQMAQMYIAELNHLLHSA 110 elephant shark

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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