Conserved Protein Domain Family
HEXIM

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pfam15313: HEXIM 
Hexamethylene bis-acetamide-inducible protein
HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Statistics
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PSSM-Id: 464638
Aligned: 22 rows
Threshold Bit Score: 98.298
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005796724 160 WKPYNKLSWEEKKALEERETVRASRMREEMFAKG-LPVAPYNTTQFLMDEHDREEPDLNTEAG-------------VRRl 225
EDO36416      27 DKEIFDFSVVPVKR-----------------AKG-RTAAPENTTQFLMDDHEKFEPFV--LSS-------------PSLs 73 
XP_002609570  79 WKPFVKLSWEERKDLEERERKRAMRVREMMFAEG-RTVAPYNTTQFLMEDHETQSX----FHS-------------PNLe 140
EDV20910      85 FSNYQNLSCQEKAELEEMAAEEATQLYNQRIQSG-LPVTPFNTTQFIMDDYE---------------------------- 135
XP_019850119  80 WKPYSKMSLEERKQVDEWEEKHVAIREAEINARSkRPVAPFNSTQFLIDDRCED----------------------QYR- 136
OWR53811       1 ------MSWQERRKVDN--TKRNNRFRKIVLTKT-Q--APFNNNQFLMEIHK-PEPENNFLLY-------------RTPs 55 
XP_006567926 129 LKPYSKQQLSYQQQLRYRSRGRLAKTGR-------QPPALYNTTQFLMDDHS-DLPDLDQKLSeaasselpatfqkPSAp 200
EGI69951      99 LKPYSKQ-LSYQQQLRSKYIGRIAKTSR-------QPPALYNTTQFLMADHS-DLPDLEQKLSeaaslevpalfpkPWAp 169
EEC12396      88 WKPYYKLSWEERRELEERESRRANRLRQQMFAHG-QPVAPYNTTQFLMEDHCVQEPDFESRNG-------------HHRh 153
EKC18378      89 WKPYEKLSWNERRELEERETVRANQKREEAFAHG-HPVAPYNTTQFLMEDHGKADQNIGEGQL-------------NRN- 153
XP_005796724 226 SGVSGRMEDTGSEEDLFDNEEEEDddgsggggsdgIgrpGNAGGEY-LQRDFSETYEMYHVESLQNMTKQELVQEYLELE 304
EDO36416      74 PNSSGCEFSSSSVRGSPVCERDLQsvtelvgnfdeL---------Y-FEKDFNDVYDSIHAETLLGLSKQELIYKYMELE 143
XP_002609570 141 VLQRQQSNDTSNSDDMPDSPEDDF----------------GMEAGF-FEKDFSETYEQFHAESLNNMSKTDLIREYLEME 203
EDV20910     136 -KARARSVNDNSDDLLDEIQRMED---------------KSENGNYsGEDEFTAHLEEIRFDKYDRMSKGELVRYCYQLD 199
XP_019850119 137 RPSRTLSFDSSSGDDVHYDLSDED------------------QEAF-LEADFNQVYLQLKLNRLEGMSKQDLISQCCNLE 197
OWR53811      56 ARTRDSSFSIDSEDNYFHSLPEDE-------------------EEY-LTKEFSSVYEDAQCERLSNMSKNELIQEYLLLE 115
XP_006567926 201 SRTRDSSFSVDSDEDYFYSSPEDE-------------------EEF-LTKEFSTAYEDLHAERLSTLSKSELIQEYLQLE 260
EGI69951     170 SRTRDSSFSVDSDEDYFYSSPEDE-------------------EEF-LTKEFSTAYEAVHEERLSTLTKTELIQEYRHLE 229
EEC12396     154 REDSVNS--VDSSDEFYSSPEDED--------------------DF-LQKQFSEAYDDVHAERLSSMSKAELVQEYLLLE 210
EKC18378     154 NSRESTDGSGSTSDSSEEMYSEEE--------------------EF-LEKEFAETYDNMHAERLQKMSKDELIKDYIEME 212
XP_005796724 305 KCMSRL 310
EDO36416     144 KKEENL 149
XP_002609570 204 KCVERL 209
EDV20910     200 KKIQQL 205
XP_019850119 198 DKVSVI 203
OWR53811     116 AKYDNL 121
XP_006567926 261 AKVDLL 266
EGI69951     230 AKMDSL 235
EEC12396     211 DRVEDL 216
EKC18378     213 TKLDRL 218
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