Conserved Protein Domain Family
SPRY_PRY_SNTX
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cd16040: SPRY_PRY_SNTX 
Stonustoxin subunit alpha or SNTX subunit alpha
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of Stonustoxin alpha proteins. Stonustoxin (SNTX) is a multifunctional lethal protein isolated from venom elaborated by the stonefish. It comprises two subunits, termed alpha and beta. SNTX elicits an array of biological responses, particularly a potent hypotension and respiratory difficulties.
Links
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Statistics
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PSSM-Id: 294002
Aligned: 89 rows
Threshold Bit Score: 245.473
Created: 27-Mar-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDQ81227     679 KPGLRKYACDLTLDPNTVNrHLSLSEEN--RKVTWRIEEqpYPDHPERFD-WKQVLCREGLT-GRCYWEAEWSGr---GA 751 rainbow trout
XP_006641391 516 ELSFVGDACQLTPDLETVHrRLSVSERN--IEMTRKKEKmpYPDHPERFEwHPQVLCREGLT-GRCYWEVEWSGk---GV 589 spotted gar
AAI34874     396 RDEFLQYACQLTLDPDTAYrQIYISRSN--RKAALKKDPqsYSESNQRFDcLPQVLCKESLSgGAYYWEVEWSGe---GA 470 zebrafish
XP_006625441 396 RAEFLKCCCQLFLDPNTVHpNLLLSEGN--RRLVRTRKVqpYPSHPERFDsYYQALCREALTgKRFYWEVEWAGr---EV 470 spotted gar
XP_006790626 507 RSDLMWYACDLTLDPNTAHcELVLSEGK--KKVKRGKTQl-YPDLPERFSkLPQVLCREKLN-GRHYWEVQLSAswlaVV 582 Neolamprologus ...
CDQ58812     308 RADFLRYSCPLTFDPNTAYkELVLFEGN--HKVMRKKTVqfYPDHPERFDgFSQVLCRESLGgFRYYWEAEWSG----EF 381 rainbow trout
AIC84040     520 RSDLLWYACNLTFDPNTVHkCITLSDDN--KHAESGKQQk-YSVHPERFNiFREVLCKEGLN-GQHYWEVEWTG----HV 591 false kelpfish
AIC84038     516 RSDLLWYACDLTFDPNTAHqQLALSDDN--KYVESGKHQk-YSKHPERFDnYRQVLCKEPLR-GRHYWELEWNG----TV 587 tassled scorpio...
Q91453       516 RRELQWYDCELTLDPETAHqVLTLSEGN--KKAVSGNTKs-PTDHLEKFShFQQVMCTKGLS-GRHYWELEWSG----YV 587 estuarine stone...
Q98989       519 RSDLLWYACDLTFDRNTINnWISLSDNDtfAASEHGKRQn-YPKHPERFVsFNQVLCNEGLM-GKHYWEVEWNG----YI 592 Synanceia horrida

CDQ81227     752 YIGVTYKGISRKGsgnDSGIGWNDKSWSLFYSv---kSFVAWHNDNp-tTIDVPSss-shRVGVYLDWPAGTLSFYRVSS 826 rainbow trout
XP_006641391 590 TIGVACRGIGRKGkgyDSCLGHNDKSWGLECRg---sGYSVWHNNN---ETVIPVss-spRVGVYLDWVGGTLSFYSVSP 662 spotted gar
AAI34874     471 SVGITYKGIKRAGygdSARIGYNRKSWSLFCSd---sSYSARHNKDq-lEIKAPYs---sRIGVFLDCAGGTLSFYTVSE 543 zebrafish
XP_006625441 471 FVGVAYRSMGRRGqglLAGLGRSSKSWGVLCSa---sGYSAWHDNQ---STAVPApr-shRVGVFLDHSRGLLSIYSVSD 543 spotted gar
XP_006790626 583 SVGVCYSQLERKGnsdLCKLGYNEKSWSCSCRyllglWYFVVHNGLk--IFKLPKgc--pKLGVFLDWHAGTLSYYVVSC 658 Neolamprologus ...
CDQ58812     382 SIGVAYKSISRKSknsHSLLGYNDKSWSLLCSd---sGYSAWHNKM---DKDLPEapratRVGVYLDYTANTVAFYSVSE 455 rainbow trout
AIC84040     592 SAGVAYVGIARKDfkpESLIGFNLKSWALCATpk--tGYVIWHNQEk-vLVSMPDpn-ftRLGVYLDWRAGSLSFYMVSS 667 false kelpfish
AIC84038     588 IAGVTYLSIGRKNidiQSVIGFNETSWTFISFpk--nGYFIKGTGIellRVGLPDpd-ftRLGVYLDCHASTLSFYKVSS 664 tassled scorpio...
Q91453       588 GAGVTYKGIGRKTstsDSSLGKNEKSWLFEYStk--sGYQQIHNSKk-tRVTVSStg-fkLLGVYLDWPAGTLSFYMVNK 663 estuarine stone...
Q98989       593 DVGIAYISIPRKEidfASAFGYNTYSWVLSYNpk--iGYIERHKKRe-yNVRAPNpg-fkRLGLFLDWRYGSISFYAVSS 668 Synanceia horrida

CDQ81227     827 dSLTHLYTFYTTF--TEPLYPGFHVwf-----dAASVSLC 859 rainbow trout
XP_006641391 663 dSMLHLHTLEAIF--TEPLYPALGAk------dNGSIRLI 694 spotted gar
AAI34874     544 -SMSLIHQFKASF--SEPVYPGFWVw------yESAVTIC 574 zebrafish
XP_006625441 544 -TMALLHRFQASF--TEPLYLGFGVvn-----pGDMSQCC 575 spotted gar
XP_006790626 659 dKLTHMYTFRTKF--SEPVHPGFRLwtlftisdEDSVLLM 696 Neolamprologus brichardi
CDQ58812     456 -AMELIHKFKAQF--SEPLYAGFGV--------GSSVSLC 484 rainbow trout
AIC84040     668 nVLHHLWTFKTKF--TEPVYPAFCIglm---qfNGKARLL 702 false kelpfish
AIC84038     665 nVLHHFHTIEIKPklSEPVYAIIRIgdvd-rpyHGRARLL 703 tassled scorpionfish
Q91453       664 aWVTHLHTFHTKF--NEAVYPAFLIgdaq-qkvNGQIKLL 700 estuarine stonefish
Q98989       669 dEVHHLHTFKTKF--TEPVYPAFSIgpa---gnHGTLRLL 703 Synanceia horrida
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