4N7Z


Conserved Protein Domain Family
Plk4BD_Cep192
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cd21856: Plk4BD_Cep192 
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Plk4-binding domain found in centrosomal protein of 192 kDa (Cep192) and similar proteins
Cep192, also called SPD-2, plays a critical role in mitotic centrosome maturation and bipolar spindle assembly. It appears to be a major regulator of pericentriolar material (PCM) recruitment and centriole duplication. It is a centrosome-specific activating scaffold for Aurora kinase A (AURKA) and polo-like kinase 1 (Plk1). Cep192 also plays a key role in centrosome recruitment of both Cep152 and Polo-like kinase 4 (Plk4). This model corresponds to a conserved region in Cep192 that is responsible for binding to the cryptic polo box (CPB) of Plk4.
Links
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Statistics
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PSSM-Id: 439317
Aligned: 11 rows
Threshold Bit Score: 49.7607
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Plk4 binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:Plk4 binding site [polypeptide binding site]
Evidence:
  • Structure:4N7Z; Homo sapiens Cep192 N-terminal fragment in complex with polo-like kinase 4 (Plk4) cryptic polo box (CBP), contacts at 4A
  • Comment:Cep192- and Cep152-derived peptides bind the cryptic polo box (CPB) of Plk4 in opposite orientations and in a mutually exclusive manner.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       ##### ##### ##  ##  #   #  #          
4N7Z_B          1 EKLILPts-lEDSSDDDIDDEMFYDDHLEAYFEQLAIPGMIYEdLEGPEPPE 51   human
Q8TEP8        201 EKLILPts-lEDSSDDDIDDEMFYDDHLEAYFEQLAIPGMIYEdLEGPEPPE 251  human
NP_001186000  182 EKLLSIas-lEGSSSDDLDDEEFYDDHLEAYFKKLLPHGMQRGvIEGQEITE 232  African clawed frog
XP_014344151  210 EKLSLAsl-eEYSTDDDIDDEELNDERIEAYFKQLVPPGMQRGdVEGQELPC 260  coelacanth
XP_007893313  457 EKLLSLasleDDSTDDDLDAEELYDDRLESYFKQLVPPGMQRGhIEGEELPE 508  elephant shark
XP_009290390  168 EKLMSLdsmnSDMTDDDIDVTQLHDEELELYFNKLIPPAMQRGrVEGQEISV 219  zebrafish
KYO35334      189 EKLLNLasfdEYSTDDDIDDGEFYDDRLEAYFEQLVPPEMLRGdTEIQELSE 240  American alligator
RXM28469      161 KRYGNP----DDDDEDDIDVDKLLDDGLESYFRQVGPPGMQRGhIEGQELPE 208  sterlet
XP_007487813  192 EKLISFrs-mEDSADEDIDDEEFYDDHLEAYFQQLAFPEMLSEdQEKQELPE 242  gray short-tailed opossum
XP_025003577  196 EKLSSLsslgGDSTDDDIDDEEFFDNQLEAYFEQLIPPDMNRGdTDIGKLSK 247  chicken
NP_081832     193 EKLLTLtn-lDSSSDDDINDEEFYDDHLEAYFEQLAIPGMMYE-AGGQESPA 242  house mouse

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