Conserved Protein Domain Family
DUF5614

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pfam18474: DUF5614 
Family of unknown function (DUF5614)
This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.
Statistics
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PSSM-Id: 436527
Aligned: 9 rows
Threshold Bit Score: 386.479
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006634451   1 MASYAMLQERIAVAKDLLERVESISGGQKKGVEGKAKLCSKLRAELKFLQKVEAGEVVIKESHLQSTNLTHLKAIVESAE 80 
Q5M888         1 MSAYSMLSERIAMAKELIKRAESLSRSKKGGIEGGAKLCSKLKSELKFLQKIESGKVAIKESHLQSTNLTHLKAIVESAE 80  Norway rat
Q5BKL1         1 MSVDSMLCDRIDIAKQLIKRAEALSRSRVGGVEGGAKLCSKLRAELKFLQKVETGKVAIKESHLRSTNLTHLQAVIESAE 80  tropical clawed...
XP_009273115   1 MSVQSLLCERIAVAKELIKRAEALSKSQKRRIEGGAKLCGKLKAELNFLHKVEAGKVAIKESHLQSTNLTHLQAIIQSAE 80 
XP_007505621  63 MSVQSMLRERIAAAEELIGRAEALSGSRKGGVEGGAKLCSKLRAELKFLRKVEAGRVAVKESHLQSTNLTHLRAVVEAAE 142
XP_006002177  13 MSADSKLHERIVSAKELIERAQALSFSQKGGIEGGAKLCSKLKAELKFLQKVEAGKVTIKESHLQSTNLTHLKAVVESAE 92 
NP_999859      1 MATYNTLQDRIRVAKELLERVDKICSRQGREVEGRAKLCSKLRAELKFLQKVEAGKVVIKESHLQSTNLTHLKAIVESAE 80 
KPP69608      44 MATHSMLKDQIKVAQELLGRVEQLCSRQTQEVEGRAKLCSKLRAELKFLQKVEAGQVQIKESHLQSTNLTHLKAIVESAE 123
XP_007542744   1 MSLQATLQDRISSAQALLQRAEHLC----PGVEGHQKLCGKLRAELRFLRRVEAGELQVKQSHLHSTNLTHLTAIVDSAQ 76 
XP_006634451  81 SLEDVVSVLHVFTYEDQAGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWQGRGQYGDKSIVKQAENFLQASRQQPVQY 160
Q5M888        81 NLEEVVSVLRVFGYTDSLGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASRQQPVQY 160 Norway rat
Q5BKL1        81 SLEEVVSVLHVFCYNDQFGEKQSLVVDVVANSGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASSQQPVQY 160 tropical clawed...
XP_009273115  81 NLEDVVSVLHVFAYEDRFGDKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSVIEQAEDFLQASCQQPVEY 160
XP_007505621 143 SLEAVVAVLHVFGYADGAGDKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDRSVVEQAEDFLRASAQQPVQY 222
XP_006002177  93 SLDDVVSVLHVFSYQDRFGVKQTIVVDVVANGGHTWVKAIGRKAEALHNIWQGRGQYGDKSIVEQAEDYLQASMQQPVQY 172
NP_999859     81 SLEKVVSVLHVFAYESPDGQKQTLVVDVVANGGHTWVKSIGRKAEALHNIWQGRGQYGDKSVIRQAEDFLEASRQQPVQY 160
KPP69608     124 SLEDVVSVLHVFTYEGPGGQKQTLVVDVVANGGHTWVKAIGRKAEALHNIWQGRGQYGDKSVVRQAEDFVQASRQQPVQY 203
XP_007542744  77 NLEDVVALLHVFSYRDAAGRCRTLVVDVVADVGLTWVKAVGRKAEALHNIWQGRGQYGDKSVVRQAEDFLLASRQMPVNY 156
XP_006634451 161 SNPHIIFAFYNGVSSPMADRLREMGISVRGDIVAVNSVAGAEeGEDALSDSscESDADGDE 221
Q5M888       161 SNPHIVFAFYNSVSSPMADKLKDMGISVRGDIVAVNSLLNHP-EEYLLSES--ESDDEGQE 218 Norway rat
Q5BKL1       161 SSPHIIFAFYNSVSKPMAEKLKEMGISVRGDIVAVNVSQENSpEENYLSGS--ESDCDGDD 219 tropical clawed frog
XP_009273115 161 SNPHIIFAFYNSVSSPMAERLKEMGISVRGDIVAVNLLAESStENEHLSAS--ESDEEGPE 219
XP_007505621 223 SSPRVVFAFYNGVSSPVADELRGMGVSVRGDIVAVNNP---PeWPEWLPPSdgESDEEAPG 280
XP_006002177 173 SNPHIIFAFYNGLSSPMAEKLKDMGISVRGDIVAVNSV---VeLNDNSNTSanESDEEPSE 230
NP_999859    161 SNPHIIFAFYNGVSSPMADKLKEMGISVRGDIVAVNTIEGGEeEDEEDQEGdhEDLVEEEE 221
KPP69608     204 SNPHIIFAFYNGVSSPMADRLREMGISVRGDIVAVNSV--VGaEETAKVGDdeESDSSYGE 262
XP_007542744 157 RHPRIVFAFYNGVSSPMADRLRHLGVAVRGDIVAVRVEe----EEEKDEGEeeERDEEEVE 213
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