Conserved Protein Domain Family
Helicase_PWI

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pfam18149: Helicase_PWI 
N-terminal helicase PWI domain
This domain is found in spliceosomal RNA helicase Brr2. Brr2 is required for the assembly of a catalytically active spliceosome on a messenger RNA precursor. The domain is found in the N-terminal region and is non-canonically PWI-like. The PWI-like domain is thought to be involved in protein-protein interactions.
Statistics
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PSSM-Id: 436309
Aligned: 29 rows
Threshold Bit Score: 112.698
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESX01024      157 DTEEFDIKSVDKYYLTRLLAQEFKdlDSYRHTELSQSINELLTKF---AEEeldmRKLESSLLQLFDY--ESNDTVRKIT 231 
XP_011275028  261 AHKALSIKDIDAFYLQRLVSSHHTdlDASAVQSLSSGLLELIESS---LAG----KEFEQRLLQIVDS--EKVELVQLLI 331 
EDO14727      280 EKNKISIFTVDEFYVERLLLKELKsiNTEMVPNLSSKILLAIEGS---SDSd---KEIEKKLLELLDF--DSLSLVNFII 351 
SHO79484      257 KDQGVSVHEVDAFWLQRLLRSHYQ--DEIEVSEKADAALEILGAS----DDv---RECENNLMDLFNY--EHMDMVQTLT 325 
EFI93765      272 DKDIVAPHEIDGFWVQRQISEAYP--DPVTAADKASAVISILGSE----SSl---RDCENQLMDLFEY--QSFHIITKFL 340 
KNE94414      295 GKHDLTIYDIDGFWLQRLIGSHFP--DPIEAESKTKEAINLLSAD---NSSl---RDLENSLVDLFDY--DKFELVSVLT 364 
KXN69250      276 SKDTVHPHEIHAHWLQKQIKEYFS--DSQEAEGKTLETKDILFSD---IDA----RECENQLMQAFDFdqEKFSLINRLI 346 
KFZ16958      304 KDKSIPAREIDAYWLQRQIGQNYA--DAHMQQVKTQQALQILSGLseeGDErt-lREIENDLMELFDY--EHHELVQKLI 378 
Q6C0Y6        246 DSDVIPATEIDSFWLQREIASLVGg-DQQESIDLSRRVFDILAGE----SSl---RETENELSEAFDF--DHLDFVAKLC 315  Yarrowia lipo...
EGX44611      306 DKEFVPAHMIDAFWLQRTIGTVYA--DVHEAATKTTTAMDLLASE---V-Pl---RQLENDLMELFDY--EHFDTVKVLT 374 
ESX01024      232 KHPLEIYFAIKLSQ--ASE-AEKSQIFDTMVSKGLESWVNQY 270 
XP_011275028  332 TNREAILWGIKLAK--ANP-EERQSILTALESSESKHLLEDL 370 
EDO14727      352 QNKYEILWGCKLSK--ANK-IDKEELIDTMIGNGLQYLVDEY 390 
SHO79484      326 KNRQVVYWCTRLAR--ASE-DERMDIEVAMREKNVGYILKRL 364 
EFI93765      341 KNRDVIFWCTKLMR--SDA-DERVNVEVAMREKGVGWILREL 379 
KNE94414      365 KHRDIIVWGTKWSR--SDE-DEKVNLAVVMREKGVGWIVKAL 403 
KXN69250      347 KNRDVIVWCTKLSEvgGPQsQEYQNIASEMTELGLDWILKAI 388 
KFZ16958      379 SNRDKVVWLTRLAK--AEDdEARGVVEREIIAEGLRWILDEL 418 
Q6C0Y6        316 HNRDRVVWITRLQR--ADG-PEKDTVKKQMTSLGLASLVSEL 354  Yarrowia lipolytica
EGX44611      375 KNREKIVWCTRLAK--AGEeDEAEGIKKEMIEAGLKGILDEV 414 
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