4JVH


Conserved Protein Domain Family
STAR_dimer

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pfam16544: STAR_dimer 
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Homodimerization region of STAR domain protein
This family is the homodimerization domain of quaking proteins. Quaking-dimer is a helix-turn-helix dimer with an additional helix in the turn region. dimerization is required for adequate RNA-binding. Quaking is a prototypical member of the STAR (signal transducer and activator of RNA) protein family, which plays key roles in post-transcriptional gene regulation by controlling mRNA translation, stability and splicing. STAR_dimer is the homodimerization domain, Qua1 of the STAR domain of a series of proteins referred to as STAR/GSG, or Signal Transduction and Activation of RNA/GRP33, Sam68, GLD-1 family. These are conserved in higher eukaryotes and are RNA-binding transcriptional regulators. The STAR domain is a KH domain flanked by two homologous regions, Qua1 and Qua2. Qua1, this family, is the homodimerization domain, and the KH plus Qua2 is the RNA-binding region.
Statistics
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PSSM-Id: 435414
Aligned: 13 rows
Threshold Bit Score: 78.1405
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JVH_A         5 KPKPTPDYLXQLXNDKKLXSSLPNfcgIFNHLERLLDEEISRVRKDXYN---DTLNGS 59 
XP_008182099  10 NTQSIADYLAQLLKDRKQITAFPN---MFMHVERLIDEEITKVRASLFE---VNGVKK 61 
EEC14144       8 sTQSIADYLAQLLKDKKQLAAFPN---VFIHLERLLDEEISKVRSSLFQ---INGMKK 59 
EFX67278      32 NTQSVADYLAQLLKDKKQLAALPN---VFHHVERLLDEEIGKVRGNLFQ---INGTEK 83 
PDM69533     107 QQTYSIDYLSQLLKDKKQLAAFPN---VFHHLERLADEEISRVRVALFQ---FEFTKK 158
CRZ24663      36 KTQYTYEYLAQLLKDKKQLEAFPN---VFHHLDRLAEEEISRVRVSLFQ---FEFAKD 87 
XP_002127447  93 KTKERVNYLQQLLKDKKQCQLYPT---IFVHVERLLDEEIVKVRSVLFQ-----NGDK 142
EKC26735       8 DERSTPEYLAQLLKDKKQIQAFPN---VFVHLEKLLDEEINRVRLQLFH---HKGNGR 59 
ESO12615      33 tDRKSSEYLTQLLNDKKALLGLPV---VFQHLDKILDEEINKVRSHLFN----VCSNK 83 
XP_006842569  22 TPDHDSQYLSELLAEHQKLAPFTE---VLPICSRLLNQEILRVSGRMPN---KGFGDH 73 
XP_005462304   6 KPRPGPDYLMQLMNDKKLMSGLPNfcgIFQHLERLLDEEIGRVRKDMYT---DMLNGS 60 
XP_006012538  13 RPRPSPDYLMQLMNEKKLMASLPNfcgIFTHLERLLDEEINRVRKDMYNdsiNGLTEK 70 
XP_011534562  10 KPKPTPDYLMQLMNDKKLMSSLPNfcgIFNHLERLLDEEISRVRKDMYNdtlNGSTEK 67 
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