Conserved Protein Domain Family
MAP2_projctn

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pfam08377: MAP2_projctn 
MAP2/Tau projection domain
This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.
Statistics
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PSSM-Id: 429957
Aligned: 3 rows
Threshold Bit Score: 1767.65
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017451788  374 DKVADVPVSEATTVLGDVHSPAVEGFVGEN--ISGEEKGTTDQE---KKETSTPSVQEPTLTETEPQTKLEETSKVSIee 448 
XP_039768624  455 DKMGDMPMSTVITQSMEVHKLTIRESHGQRgcGVGEDKDIPRWEndlRKEHFLPNGQKFALFESEPYRKPEEKSSVLV-- 532 
P11137        377 DKMAEAPPSEAMTLPKDAHIPVVEEHVMGK--VLEEEKEAINQEtvqQRDTFTPSGQEPILTEKETELKLEEKTTISDke 454  human
XP_017451788  449 TVAKEEESLKLKDDKAGVIQTSTEHSFSKEDQKGEEQTIEALKQDSFPISLEQAVTDAAMATKTLEKVTSEPEAVSEKRe 528 
XP_039768624  533 SLPQDSKLLKGLDEEKSTTRSLGGQTIKKEEPPSKGAQVDQFRRDSFPGAQGRDLMLAAALSETLDKMPVAPSPRSDPA- 611 
P11137        455 AVPKESKPPKPADEEIGIIQTSTEHTFS--EQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSs 532  human
XP_017451788  529 iQGLFEEDIADKS-KLEGAGSATVAEvEMPFYEDKSGMSKYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESLDTVSP 607 
XP_039768624  612 -RSLSQEREIGKDiRADKAGAPPPTE-ERPLDEDKSGMSKYFETSTLKEEATKSLQQDSDYYELSDSKESAYESYDTVAP 689 
P11137        533 iQELFEMRVDDKD-KIEGVGAATSAElDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSP 611  human
XP_017451788  608 KNQQDEKELlaka-sqpSPPAHEAGYSTLAQSYtsdhPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 686 
XP_039768624  690 MFKDGDQES--------SAPACEVGYSTLAQGY----PSDIAEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 757 
P11137        612 MHKNGDKEFqtgkesqpSPPAQEAGYSTLAQSY----PSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSL 687  human
XP_017451788  687 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPPTTPAVEKIPCFPIESK--- 763 
XP_039768624  758 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPGLEKAPGFPTEGReek 837 
P11137        688 GLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESK--- 764  human
XP_017451788  764 ----------EEEDKTEQA----------KVTGGQTTQVETSSESPFPAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVS 823 
XP_039768624  838 eeegeeeeeeEEEEEVEEAeqaegqkkagKAVEVESSQVESPSESPFLAKEYYKNGAVMAPDLPEMLDLAGTRSRLASVS 917 
P11137        765 ----------EEE-QIEKV----------KATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVS 823  human
XP_017451788  824 ADAEVARRKSVPSEAVVAESSTG-LPPVADDSQ-PVKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDD 901 
XP_039768624  918 ADTESARRKSVPADVGGHDSGAGvLSPIGNKNHvAVKDDSQMEDLGYCVFNKYTVPLPSPVQDSENLQGDSGLFYEGADD 997 
P11137        824 ADAEVARRKSVPSETVVEDSRTG-LPPVTDENHvIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDD 902  human
XP_017451788  902 KVRRDLATDLSLIEVKLAAAGRVKDEFTAEKEASPPSSADKSGLSREFDQDRKANDKLDTVLEKSEEHVDSK------EH 975 
XP_039768624  998 KLRRDLATDLSLIEVKLAATGRVKQDVGGEKEPSPPVSGDKAGLSRELDQDRKATDKLDTVLEKGEEPMDSKetllpeEH 1077
P11137        903 KVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSK------EH 976  human
XP_017451788  976 AKESE-EVGDKVELFGLGVTYEQTSAKELITTKETAP---ERAEKGLSSVPEVAEVETTTKADQGLDVAAKKDDQSPLdI 1051
XP_039768624 1078 GKLGPgEVVTKVEMVSSEPAVDLASIQVMTQSQDTSPfmtEKVEPLLGSVPEVAETEPLPKAEPRTDPSAKADPSQPV-V 1156
P11137        977 AKKTE-EAGDEIETFGLGVTYEQALAKDLSIPTDASS---EKAEKGLSSVPEIAEVEPSKKVEQGLDFAV----QGQLdV 1048 human
XP_017451788 1052 KVSDFGQMASGMSVDAGKTIelkfeVDQQLTLSSEAPQETDSFMGIESSHVKDGAKVSETEVKEKVAKPDLVHQEAVDKE 1131
XP_039768624 1157 QVSDFGSTAAEQDGASQGPA-----AQQEGAGLARGGQDVELLVGAEAGDGKEGTRGSEAEIKEKVAKPDLVHQEAVDKE 1231
P11137       1049 KISDFGQMASGLNIDDRRATelkleATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKE 1128 human
XP_017451788 1132 ESYESSGEH----ESLTMESLKPDEGKKETSPETSLIQDEVALKlSVEIPCPPpvSEADSSIDEKAEVQMEFIQLPKEES 1207
XP_039768624 1232 ESYESSGEHdvtpEGGAGEPSKPDEGKKEPAKEPPTLPDEVTVR-ALEAELPP--SSVDAVLVEGADIQMEPIQQPKRDS 1308
P11137       1129 ESYESSGEH----ESLTMESLKADEGKKETSPESSLIQDEIAVKlSVEIPCPPavSEADLATDERADVQMEFIQGPKEES 1204 human
XP_017451788 1208 TETPDIPAIPSDVTQPqpeAVVSEPAEVRGEE-----EEIEAEGEYDKLLFRSDTLQITDLLVPGSREEF----VETCPg 1278
XP_039768624 1309 QEAPGISITPSEALEP---TLLKPGSEASADEnkegqEEVEARGESDRLLFRSETLQLADLSIPTDREESekrgVEDVP- 1384
P11137       1205 KETPDISITPSDVAEPlheTIVSEPAEIQSEE-----EEIEAQGEYDKLLFRSDTLQITDLGVSGAREEF----VETCPs 1275 human
XP_017451788 1279 EHKGVVESVVTIEDDFITVVQTTTDEGELGSHSVRFAAPVQPEEERRPYPH----------------------------D 1330
XP_039768624 1385 EHKGGIESVVTIEDDFITVVQTTTDDGESGSHSVRFAALDQAEVESRPSPPggeeeeeeeeeeeeegggggggeeeeeeA 1464
P11137       1276 EHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPH----------------------------D 1327 human
XP_017451788 1331 -EELEVLMAAEAQAEPKDGSPDAPATPEK-EEVPFSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSILTEQLET 1408
XP_039768624 1465 -SEPEAEELMDDRPEPKEGSPEAPASPDKeEEVGLSEYKTETLDDYRDETTIDDSIMDADSLWVDTQDDDRSIMTEQLET 1543
P11137       1328 eEEFEVEEAAEAQAEPKDGSPEAPASPER-EEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLET 1406 human
XP_017451788 1409 IPKEERAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLI 1488
XP_039768624 1544 VPKEEKSEKEARRPSLDKHRKEKPFKAGRGRISTPERKIAKKEPSTVSRDEVRKKKAVYKKAELAKKTEVQAHSPSRKFI 1623
P11137       1407 IPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFI 1486 human
XP_017451788 1489 LKPAIKYTRPTHLSCVKRK 1507
XP_039768624 1624 LKPAIKYTRPTHLSCVKRK 1642
P11137       1487 LKPAIKYTRPTHLSCVKRK 1505 human
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