Conserved Protein Domain Family
FAM210A-B_dom

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pfam06916: FAM210A-B_dom 
FAM210A/B-like domain
This domain is found in mitochondrial proteins, including FAM210A and B, which contains a transmembrane peptide. Its function is not clear. FAM210A, a protein essential in maintaining skeletal muscle structure and strength, interacts with mitochondrial translation elongation factor EF-Tu and promotes mitochondrial protein expression. In FAM210A, this domain is responsible for binding EF-Tu. FAM210B plays a role in erythroid differentiation and is involved in cell proliferation and tumour cell growth suppression.
Statistics
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PSSM-Id: 429191
Aligned: 25 rows
Threshold Bit Score: 86.1563
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6C1L2             115 TGIKALVQKYGWVALGVYLSLSTIDLPICWLGVHSv---GLDkVVEWQVYLKELvgwkttpkeelqednvegsdiantvt 191 Yarrowia ...
WGS:AAAA:OsI_32226   5 ARMKELMRKYGKVAIGVHLSVSCASITGLYVAIDN----NVD-VDAIFRRIGISpsggvagdeaaet------------- 66 
Q9SKR7               3 TRLKEIVKKYGKVALGVHFSVSGVSISGFYIAIKN----NVD-VESLLEKYQIPwfsskenpnpsl-------------- 63  thale cress
Q9U237              82 AKVKYYFKRYWYIAVPAHAASCTAWFIALYLVVKS----GVD-VISLLEWLHMP-------------------------- 130 Caenorhab...
Q9VR55             109 AKFKHMYKQYWYVLIPVHVLTSVGWFGGFYYLSKS----GVD-VPALLQYIHLS-------------------------- 157 fruit fly
Q5XIJ4             125 QRFKKTFRQYGKVLIPVHLITSGIWFGTFYYASIK----GVN-VIPFLEFLGLP-------------------------- 173 Norway rat
Q1MTD4              83 QRFKKTFKQYGKVMIPVHLLTSTMWFGTFYYAAMK----GVN-LVPFLEYVGFP-------------------------- 131 zebrafish
XP_001614075       250 INVKRFFQKYGYIGLGTYFVVFFVTFSCCYFFVHFkyisLSD-VTYWSEKMHLTky------------------------ 304
Q5CS20             106 GKMKNLWNKYGYTSIFTYFTIYLATFISFWILAINniinAAK-LIKLISVLRLDnh------------------------ 160 Cryptospo...
Q54G09             138 EKIKYMFSKYGKLALIVHFGIYFATMGSFYVLFSS----GVD-INNALDFLHIP-------------------------- 186 Dictyoste...
Q6C1L2             192 galamvtpdigaavedqkvdeklpetsPTESYWFSKQ--MWAEFAVAYAIHKSLIFIRLPITAAITPS 257 Yarrowia lipolytica
WGS:AAAA:OsI_32226  67 --------------ptpsaavpeeappRNRTRELVAS--SGGALALALMCNKALLPVRVPVTLALTPP 118
Q9SKR7              64 ---------------dlkleeqgsvtsDNKTKQLAKS--AGGALALAVLCNKALFPIRVPITMALTPP 114 thale cress
Q9U237             131 ---------------------------DAIVEKVKNTpeTAGVVVVSLILYKIAMPFRYMTTLLLIQA 171 Caenorhabditis elegans
Q9VR55             158 ---------------------------ENIIEKVQGS--DMGHYAIAYLCYKVATPLRYALTLGCTTV 196 fruit fly
Q5XIJ4             174 ---------------------------DSVVDILKNS--QSGNALTAYAMFKIATPARYTVTLGGTSF 212 Norway rat
Q1MTD4             132 ---------------------------DKVVKLLENS--QSGYALTAYAMYKIATPARYTVTLGGTSL 170 zebrafish
XP_001614075       305 --------------------------vDDNLQKKIDS--LWGELLFAYIASKVTEPVRIVITILITPY 344
Q5CS20             161 -------------------------inSSKIEQRMET--PFGKLFIAWISTKIVEPFRLFSTITLTPY 201 Cryptosporidium parvum
Q54G09             187 ---------------------------RNAVNP------SLGAFAVAFACTKISTVVRTPLTLITVPL 221 Dictyostelium discoid...
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