6IEH


Conserved Protein Domain Family
NRDE2_MID
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cd22200: NRDE2_MID 
MTR4-interacting domain (MID) found in nuclear exosome regulator NRDE2 and similar proteins
NRDE2 is a protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX, an essential factor directing various RNAs to exosomal degradation. NRDE2 negatively regulates exosome functions by inhibiting the RNA helicase MTR4 recruitment and exosome interaction. This model corresponds to the N-terminal MTR4-interacting domain (MID) of NRDE2.
Links
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Statistics
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PSSM-Id: 412062
Aligned: 26 rows
Threshold Bit Score: 88.9224
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
MTR4 binding
Conserved site includes 63 residues -Click on image for an interactive view with Cn3D
Feature 1:MTR4 binding site [polypeptide binding site]
Evidence:
  • Structure:6IEH: Homo sapiens NRDE2 in complex with MTR4; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #########  ##   ## # ########## #####  ###   ###       ###             ## ##  ##
6IEH_A          1 SFRTDKKPDPANWEYKSLYRGDIARYKRKGD-SCLGINPKKQc--ISWEGtsteKKHSRKq----------VERYFTKKS 67   human
XP_020774937  143 AFCVDQKPDPANWTYKSLYRGDVARYRRKGA-SILGIDPHREg--VTWDDsesnKKQKAKdkknrggggfgDERYYSTAN 219  great blue-sp...
XP_022332210  140 AFRIDRKSNIHNWKYESLYKGHIASFSNLFQ-YTLGGETILKggeTTMKDs--kRKSKEK-----------MKRYFSREN 205  eastern oyster
XP_028836886  113 PFCVYRKADAANWQYKSLYRGDIARYRRKGA-SCLGLDPRKQa--VSWSEggpgRKRSDRk----------SDRYYSTAV 179  denticle herring
XP_022104815  197 GFFIDVKADRSNLCFNSLHFTDIVAYHRVGQ-SCLGLDTQRQs--VTWKSat-kAKKKHKae-------snTFRYFTRDL 265  crown-of-thor...
XP_006823850  232 AFRIDVKGDKNNRAFQSLYYLDTARYHSQHR-LCLGLGKKQS---IKWTDsdkvQKKKKNn----------SDRYYGKHA 297  Saccoglossus ...
XP_002610627   15 AFRVDKKPDKENLVYGSLYRLQLANYRRFGQ-SCLGLGRREG---IRWSEks-sKKRKIKrg--------hDSRYCSEKE 81   Florida lancelet
XP_030855338  253 PFYVDEKSDRNNLCFKTLNHTDLAFYRRLGK-SCLGLDSEKQm--VDWRDg--kDKKKEKkhs------gnVKRYFEQVY 321  purple sea ur...
XP_020618248  192 AFRLHRKPDIANRMYNTLYRLDIALYKMRSNvTCLGLSKHQV---IELTEqk-gKKKKKAr---------pVERYWNVND 258  Orbicella fav...
XP_003385086  130 AYRLHKKPDPSNLSYDTLYSGDQASYKRYYGnLCLGLGWSQS---IKFTDk---RNRVAKgsnq----eeaKKRYYEEAL 199  Amphimedon qu...

Feature 1         #####                   ####              ##########
6IEH_A         68 VGLMNIdgv-----------aiSSKTEPPs-----------sEPISFIPVKD 97   human
XP_020774937  220 QRLLISesp-----------vlLLPTETPenc--------inRGAPFLAFCD 252  great blue-spotted mudskipper
XP_022332210  206 KVLTSQapl-----------shLLPKKVPd-----------nSPSDFLSVPL 235  eastern oyster
XP_028836886  180 QQLLRSdg-------------hPALPAPPdqrgg----dstgSLALFIPVPA 214  denticle herring
XP_022104815  266 VDLVDDnve-----------vhVGSTEVSqaqtfqqrtnptqSTDSYIPIDR 306  crown-of-thorns starfish
XP_006823850  298 VSLLNDdnl-----------rlLDLSKPKfeskpg--ghsqsGRMTYIPLGI 336  Saccoglossus kowalevskii
XP_002610627   82 VAKVLHdkvmrv----evvrtsQGKPQSEv------------QSSHYIPLDR 117  Florida lancelet
XP_030855338  322 TVDDVErvpaaerkqdesagmdMILEKKS-------------AEMPYIPVKS 360  purple sea urchin
XP_020618248  259 FQVPGSteni--------sitlSSITKKPdqrs------nlaDVRGYVPLEL 296  Orbicella faveolata
XP_003385086  200 DTTDTQl---------------TFIPRPVhaacl----seeeEEVEEEEVKD 232  Amphimedon queenslandica

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