Conserved Protein Domain Family
PTZ00482

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PTZ00482: PTZ00482 
membrane-attack complex/perforin (MACPF) Superfamily; Provisional
Statistics
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PSSM-Id: 240433
Aligned: 5 rows
Threshold Bit Score: 1248.61
Created: 9-Dec-2010
Updated: 22-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
237836795    1 MLLSAIGGIGPTESRLQHIPFSTTRYLPIRSHVLQSTVeRIESPEALNEVPTKVERNEFTEKGDKTEQVLTAQADHKSLL 80  
237833157    4 TLSPPVEHASRAGSYLPKLPFAGLFKAGFKVACLLVGV-TLCVVQILLLDAAGSKPYEQKHAGLSYRSFWRSIRPHHVPT 82  
124505319    4 RILKKHYYVVFILLYLYDISCFKCIRLNNRSIYKNKYK------NNVHIGTNENIRSIEKYSNVLCNSILCKNDKISSFI 77  
156094597    4 RNINSLLAIWCILFSICEYGYVGSLRIGLRRNYSQGDSsDRLGGSDVDVRRSGELMDLGKNANILCNNISCNSKKEASFL 83  
221052646    4 GNINNLLAIWCIIFSIYEYGYVGSLRIGLRRNYSQSRNpDQYGESEVDFRTSGQLRDLGKHANILYNNISYNTKNEASFL 83  
237836795   81 EGRsvrlESTSTAPDDDFDFLFEDdtpkkpksrvnkgtssDETSPGDRSSGEGSSDSDSllsvvHRTKGNATQANKNQTR 160 
237833157   83 AIA----GSLAQMKDDEFDFDWDD----------------EEYDGGNAADDEQSTDAES-----DGDPDALTMTKQDSTN 137 
124505319   78 NQR----KNVDDDDESENDDMYESttagsssetdnesdeeENDSSDNNNSDEEQIENSNnnnsdEEQNDSSSNDNNDEEN 153 
156094597   84 SQK----KQLEDDDDDELAALYND----------------DDDDASTTTGGGSETSDDDelelpDQDEGADEGEAEDQLA 143 
221052646   84 NQK----KQLDDDDDDDLGDLYID----------------DDDDASTATGGGSATSDDDdlelpDKDEEGDEDAKNQQIS 143 
237836795  161 ithpkskaqhqkkvtkkqgipgsdslgtssadfDFDIDSSSNTQADDSQRQSlgdssaldlfgSDTGDTGDIFGFSNSSS 240 
237833157  138 ---------------------------------AFNVNEKSYVSTTQNARQS-----------EQDFPTSSTSGFSNFGN 173 
124505319  154 ---------------------------------EEQDDVMDNDQNDKKIKHSfnlaneskhtkEERVKEEKKLKIYDFIN 200 
156094597  144 -----------------------------------TQEDSDNSGTDQGLKKKvnlsrheklieDKKQQTENTFKKYRFGD 188 
221052646  144 ------------------------------------QDDAESSGREEGLKKNvklskqeklieDKKEQTNNTFKKYLFKD 187 
237836795  241 DGGNAAANDG-GLFSSSGMGPTGASDETSanplgsilggvlnpfaqqqsitpmtdkadewskenmkafeekmpkkmrDDG 319 
237833157  174 VGTPAWARPGrGEAAPEPPAPVNSSSGQGpepafg------------------------------------alrrsiDAS 217 
124505319  201 DKEKR----------------LNFNGDQK------------------------------------------------DED 216 
156094597  189 EEEESEEKSP-GKSKSLDPSSLDDDDGEG------------------------------------------------DDD 219 
221052646  188 DDEEESKKKLsGKSKSRDSNSLDDDNDKD------------------------------------------------DSG 219 
237836795  320 SPDSwykqavpqesvadlnrmrenrriaeenraaaplsaVYTKATKTVPAINYLGAGYDHVRGNPVGDPSSMGDPGIRPP 399 
237833157  218 APES-----------------------------------MYTRAVETAPATNFLGVGYDSIKGNPIGDPDMMVDPGLRSP 262 
124505319  217 NEENddkden-----------------------tlenrnIISKHTSVFPGLYFIGIGYNLLFGNPLGEADSLIDPGYRAQ 273 
156094597  220 DDGDerekkq------------------------sntrkAMKKDLDVFPGLYFAGIGYDSLFGNPLGEADSLTDPGYRGQ 275 
221052646  220 DDDDsegdkt-----------------------rsntrdAMKKDLSVFPGMYFAGIGYDSLFGNPLGESDSLTDPGYRGQ 276 
237836795  400 VLRFTYAQNEDGVSNDLTVLQPLGGYVRQYVACRQSETISELSNLSDYQNELSVDASLqGGDPIGLNSFSASTGYRDFAK 479 
237833157  263 IIVFSFQQDPDGVTNDLNYLQPLGAFTRPFSACRQSENVNELDTLSDYQKVLSVDAALhGGDSLGINSFSGSTGYKEFAQ 342 
124505319  274 IYLMEWALSKEGIANDLSTLQPVNGWIRKENACSRVESITECSSISDYTKSLSAEAKV-SGSYWGIASFSASTGYSSFLH 352 
156094597  276 IILMNWELSNKGVANDLATLQPLNGWIRKENACSRAESIKECSSVSDYTKNLTAEASV-SGSYMGFGAFSASTGYKKFLQ 354 
221052646  277 IILMNWEFSNKGVANDLATLQPLNGWIRKENACSRAESIKECSSISDYTKNLTAEASV-SGSYMGFGAFSASTGYKKFLQ 355 
237836795  480 EVSKKDTRTYMLKNYCMRYEAGVAQsnHFKWNVTIAFAAGVSQLPDVFDAHNPECACSAEQWRQDQNAEACTktNVPIWI 559 
237833157  343 DVSSKANKSFMLKTYCIRYEAGLAQtdSFKWNYTLAFDDAVAHLPVTFDGNERDTPCSVQQWRADHMADGCQqtNIPIWM 422 
124505319  353 EVTKRSKKTFLVKSNCVKYTIGLPP--YIPWDKTTAYKNAVNELPAVFTGLDKESECPSDVYEENKTKSNCE--NVSLWM 428 
156094597  355 EASKRTSKTYLVKSNCVKYTVGLPP--YVRWEQTTAFKNAVNGLPPHFTGLEADSECASDVYEQKKTSEECE--TVHAWI 430 
221052646  356 ETSKRTTKTYLIKSNCVKYTVGLPP--YVHWEQTTAFKNAVDGLPPHFIGLEAESECASDVYEQKKTSEECE--SVHAWI 431 
237836795  560 SFIEQFGTHFLVRLFAGGKMTYQVTAKRSEVEKMRNMGIDVKTQLKMQLGGVSGGAGQGTSSKKNQSSSEYQMNVQKETL 639 
237833157  423 AFIEQFGTHYTARLYAGGKMTYQVTMKSSDVKALKKKGVDVKAEVKLMLGGFSAGASSQVKTNQDSASQLRSLNVEKEAL 502 
124505319  429 KFFDIYGTHIIYESQLGGKITKIINVSTSSIEQMKKNGVSVKAKIQAQFGFGSAGGSTDVNSSNSSANDEQSYDMNEQLI 508 
156094597  431 RFFKTYGTHVIMEAQLGGKITKIIRVENSSVNQMKKDGVSVKAQIKAQFGFASVGGSTNVSSDHSSKKNEDNYEMSEQLV 510 
221052646  432 TFFKTYGTHIIMEAQLGGKITKVVRVENTSVNQMKKDGISVKAQVKAQFGFASVGGSTNVSSDNSSKTNENNYEMSEQLV 511 
237836795  640 VIGGRPPGNVSDPAALAAWADTVEELPMPVKFEVQPLYHLLPVEK-QEAFKQAVTFYSKSVGLTPQDlsALTGVTRNLPK 718 
237833157  503 VIGGKPPADVSDPKAIAAWANSVDALPMPVKLELLPLQNLLPEDK-REAFTHAVTYYSKAFGMSAMDvqSLEGTARSIQD 581 
124505319  509 VIGGNPIKDVTKEENLFEWSKTVTNHPMPINIKLTPISDSFDSDDlKESYDKAIIYYSRLYGLSPHD--TMQKDDKDIIK 586 
156094597  511 VIGGNPIKDVTKEENLYEWSKTVSTNPMPINIKLLPISTIFDSDDlKNSYEKALIYYTRLYGFSPHD--TMQKDEKDIVK 588 
221052646  512 VIGGNPIKDVTKEENLYEWSKTVSTNPMPINIRLLPISTIFESDDlKSSYEKALIYYTRLYGFSPHD--TMQKDEKDIVK 589 
237836795  719 QLTQATQVAWSGPPPGFAKCPEGQVVILGFAMHLNFK---EPGTDNFRIISCPPGREKCDGVGTASSETDEGRIYILCGE 795 
237833157  582 VLKDVTQIAWAGAPPGYARCPREQVVLFGFAMRFNFKvtiSNNLANYHIAPCTAGREKCDGIGAEEAAGDDERIYMACGP 661 
124505319  587 ILTNADTVTKNSAPPINAQCPHGKVVMFGFSLKQNFWd-nTNALKGYNIEVCEAGSNSCTSKQGSSNKYDTSYLYMECGD 665 
156094597  589 ILTASTTVTKTGPPPISAECPHNMVVLFGFVVKQNFWd-hTNKLQSYEMEICESGASSCTSKQGNTNKYDVSYTYIECGP 667 
221052646  590 ILTASTTVTNIGAPPISAECPHNMVVLFGFVIRQNFWd-hTNKLRSYEMEICESGMSTCTSKQGSTNKYDVSYTYIECGA 668 
237836795  796 EPINEIQQVVAESpahaGASVLEASCPDETVVVGGFGISVRGGSDGLDSFS-IESCTTGQTICTKAPTRGSEKNFLWMMC 874 
237833157  662 EVVNEFYQVVAETe--aGENVAVATCPEDTVIAFGFGISIGTGFYSSENTQ-VEPCTAGQTRCTKARTSNTVKSYVWMVC 738 
124505319  666 QPLPFSEQVISES----TSTYNTVKCPNDYSILLGFGISSSSGRINSAEYVySTPCIPGMKSCSLNMNNDNQKSYIYVLC 741 
156094597  668 QALPFTEQVVSVS----GTTYNSVKCPNDYSVLFGFGMATSSGRHQSALYSyFTPCRPGLKSCSLNMNEHDDKSYIYLVC 743 
221052646  669 QALPFIEQVVNVS----GTTYNSLKCPNDYSVLFGFGMATSSGKHQSALYTyFTPCRPGMKSCSLNMNNQDDKSYIYLVC 744 
237836795  875 VDKQ-YPGLRELVNVAELGSHGNANKRAVNSDGNVDVKCPANSSIVLGYVMEAHTNLQFVRDKFLQCPENASECKMTGKG 953 
237833157  739 AEKS-FPGIAQLNNIAEVGTRGKANSRMKNTDGIVNVSCGADERTLLGLALEVHTHMPSVRKAFKVCTHDSNSCALNGAG 817 
124505319  742 VDTTiWSGVNNLSLVALDGAHGKVNRSKKYSDGELVGTCPLDGTVLTGFKVEFHTSSPYVQTPFEKCAKSLKACSVHGSG 821 
156094597  744 VDATiWTGLNALSMIAKDDLHSAVNRYQQFNDGELVVTCPSEGTILTGFYGETHTSSPYVTVPFGKCAKSLKACSVHGSG 823 
221052646  745 VDATiWTGLNSLSLIAKDDLHTPVNKYKQFNDGELIVTCPSEGTILTGFYGETHTSSPYVKAPFGKCAKSLKACSVHGCG 824 
237836795  954 VDHGMLwlfDRHALFGWIICKTVN 977 
237833157  818 EQLTVLy-vDRHALFGWALCGRRH 840 
124505319  822 HAIGIQ---NFKSLFIYMLCKNNK 842 
156094597  824 QAIGIH---NYRTLFTVALCKNN- 843 
221052646  825 QAIGMH---NYRTLFVVALCKND- 844 
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