Conserved Protein Domain Family
Thioredoxin_like

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cl00388: Thioredoxin_like Superfamily 
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
The thioredoxin (TRX)-like superfamily is a large, diverse group of proteins containing a TRX fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of target proteins via the reversible oxidation of their active site dithiol. The PDO members of this superfamily include the families of TRX, protein disulfide isomerase (PDI), tlpA, glutaredoxin, NrdH redoxin, and bacterial Dsb proteins (DsbA, DsbC, DsbG, DsbE, DsbDgamma). Members of the superfamily that do not function as PDOs but contain a TRX-fold domain include phosducins, peroxiredoxins, glutathione (GSH) peroxidases, SCO proteins, GSH transferases (GST, N-terminal domain), arsenic reductases, TRX-like ferredoxins and calsequestrin, among others.
Links
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Taxonomy: root
PubMed: 814 links
Book:63 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00388
PSSM Id: 469754
Name: Thioredoxin_like
Created: 8-Feb-2008
Updated: 4-Oct-2023
Superfamily
Curated CD Hierarchy
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