Conserved Protein Domain Family
CTD
?
smart01104: CTD 
Spt5 C-terminal nonapeptide repeat binding Spt4
The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.
Links
?
Statistics
?
PSSM-Id: 215026
Aligned: 19 rows
Threshold Bit Score: 37.116
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_829174    1283 AGTTP-AFG-Qg-aAAGTTPAF----GqgaaaGTTPafgqG--------VtAGTTPAFGQGAAAGTTPAFGQGAAANKAS 1347 Trypanosoma b...
XP_566970     853 GGKTPsAAN-A---SGGKTPAW----G-----ASGG----K--------TpAYG------MASGGKTPAYGMQGGKTPNA 901  Cryptococcus ...
XP_001231045  825 GAQTP-VY------SGSKTPLH----G-----SQTP----Q--------Y-----DPGSRTPYGSMTPSHDG--SMTPRH 869  Anopheles gam...
XP_751976     854 SSRTP-AWGgA---SSARTPAWagisG-----SRTP----AwkmdgsrtSnPYDGSRTAYGGAGSRTPAWN-AGARTPYD 919  Aspergillus f...
EFY91504      846 GGRTP-AWK-AqdySGSRTPAWa--dG-----SRTV---------------NPYDGSRTAYGSGSRTPAW-QSGARTPAL 900  Metarhizium a...
XP_001371550  572 rsrsP-ATR-Gr--SRSRTPAR----R-----GRSR------------------SRTPARRRSRSRTPARRRSRSRTPAR 620  gray short-ta...
XP_501728     814 GSRTP-AAN-A---GGAQTPAW----G-----AMG-------------------NKTPSWGASESRTPAWGG--AKTPAW 858  Yarrowia lipo...
NP_502283     812 GSKTP-MYG-A------QTPMY----G-----SMTPa---------------YDGGRTPAYGEGGRTPAYG---SKTPAY 856  nematode
XP_002082230  615 GAQTP-SYT-A---AGSKTPLV----G-----SQTP-----------------NWDTDTRTPYGTMTPSHDG--SMTPRH 661  Drosophila si...
NP_593191     869 GSRTP-AWN-----SGNKTPAW----Nv---gNKTP----------------AWN-------SGAKTPAWNA-GNKTPSW 911  Schizosacchar...

XP_829174    1348 VFGqgv------taGTTPAF-GQGAGGCVSNSVFGTT-------------PA-----------S---------------- 1380 Trypanosoma b...
XP_566970     902 YAMappg----psgGRTPAY-GAYGRPEASGSRPSVM-------------AP-----------Psapysapysaptpagn 952  Cryptococcus ...
XP_001231045  870 GAWdp-------tvSNTPAR----SNDFDFMEEPSPS-------------P----------------------------- 896  Anopheles gam...
XP_751976     920 SGSgssgfdafaagSRTPAW-GGANAGGRTPAWSASS-------------SAgsgnrdsrgydA---------------- 969  Aspergillus f...
EFY91504      901 GDAfg-------agSRTPAYaGGGADGWASGSKTPAWgasaptpgasgtdSW-----------G---------------- 946  Metarhizium a...
XP_001371550  621 RGRs---------rSRTPAR-RRSRTRSPVRRRSRTR-------------SP-----------A---------------- 650  gray short-ta...
XP_501728     859 GAAga--------gSKTPAF-G--VARTPSWKSSSAG-------------TY-----------G---------------- 887  Yarrowia lipo...
NP_502283     857 GDLdeh------ssSRTPAY-GNDSSRTP--------------------------------------------------- 878  nematode
XP_002082230  662 -GAwdp------taNTTPAR-N-NDFDYS-LEEPSPS-------------P----------------------------- 689  Drosophila si...
NP_593191     912 Nn-----------gTKTPAW-NANQTPMVANGTNTSW-------------GQ-----------T---------------- 939  Schizosacchar...

XP_829174    1381 -----GgcelgticgfgsdpsgvkslrvNlG-----------------------------------ANCG---VGTPS-- 1415 Trypanosoma b...
XP_566970     953 gaptpA----------------------IpG-----------------------------------NPYT---APTPY-- 970  Cryptococcus ...
XP_001231045  897 -------------------------------------------------------------------GYN---PSTPG-- 904  Anopheles gam...
XP_751976     970 -----P----------------------NpG-----------------------------------GAYS---APTPG-- 982  Aspergillus f...
EFY91504      947 -----Y----------------------TpG-----------------------------------ATTGgydAPTPGaa 964  Metarhizium a...
XP_001371550  651 -----Rr-----------------------GgrsrsrtparrggrsrsrtparrggrsrsrtparrGRSR---SRTPA-- 697  gray short-ta...
XP_501728     888 -----Gsssrn-------------kgweDlG-----------------------------------SGNS---APTPG-- 909  Yarrowia lipo...
NP_502283     879 ----------------------------AyG-----------------------------------SADG---ARTPA-- 890  nematode
XP_002082230  690 ----------------------------Gy---------------------------------------N---PSTPG-- 697  Drosophila si...
NP_593191     940 -----Payggfse---------tnwdteDnS-----------------------------------KPYT---APTPG-- 965  Schizosacchar...

XP_829174    1416 -VFGVpghvsspqV------------------------APFGSAATSHVFQSSSFS 1446 Trypanosoma brucei TREU927
XP_566970     971 -GAPT--------PyaaptpgmpslsaptpgpgagiapTPFGAPTPYGAQSYGASA 1017 Cryptococcus neoformans var. neoforma...
XP_001231045  905 -Y-QI--------N------------------------TPYAPHTPGNMFNADNYS 926  Anopheles gambiae str. PEST
XP_751976     983 ---------------------------------------AYTAPTPGA---SAPTP 996  Aspergillus fumigatus Af293
EFY91504      965 iGAPT--------P------------------------GAMNAPTPGAYSAPTPAA 988  Metarhizium acridum CQMa 102
XP_001371550  698 -RRGRt--------------------------------RSRTPARR-GRSRTRSPV 719  gray short-tailed opossum
XP_501728     910 -YAAAtpg---emM------------------------GAPTPGAAHHPWEDSAPT 937  Yarrowia lipolytica CLIB122
NP_502283     891 -YGSTe------gG------------------------RTPAYGSMDN-----SRT 910  nematode
XP_002082230  698 -Yq---------mT------------------------SQFAPQTPGT--LYGSDR 717  Drosophila simulans
NP_593191     966 ---------------------------------------AWAAPTPGGW--DDEEG 980  Schizosaccharomyces pombe 972h-
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap