5ZWN


Conserved Protein Domain Family
Snu56_snRNP

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pfam19097: Snu56_snRNP 
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Snu56-like U1 small nuclear ribonucleoprotein component
This family is a component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, which targets pre-mRNA to the splicing pathway.
Statistics
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PSSM-Id: 436963
Aligned: 21 rows
Threshold Bit Score: 327.71
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZWN_W        30 DGQRRKVGNSEAFQSFDIWKNLDRIRS-TKKN---AGQFIKGSLLILPMRT-EDKQQFDECMDELHKYISKDILRCYPqk 104 Saccharomyces c...
Q6FM44        20 LNKKAKRHPALTQDSYDLWKNLDRIRK-LHKN---SDKVLKRSVVLIPLSC-ETNNTIVQCIQHLLRYVDQERLHFKTvs 94  [Candida] glabrata
XP_002553945  12 QGSRSNTKKPDVHESSSLLSIAEAVSQ-RNTN---VTKVIKKSQIFVSLTA-LEAKQLSRC--KLEELANNQSLQLIEke 84 
SCU85222      12 NGSRISTKRADSYDSNSLLSAFKSLGR-KRPG---IQQVIRKSSVFVPITD-TDIQFYQHS--KLANEIKEDTLQFVHhq 84 
CEP62034      12 NGPRSRVKRPDSYDQSSLVATYRFFNR-KKAE---ASTVMRRSAVFLLINK-DEYSKFENS--RAFAEIRVNIVEFVQle 84 
SCW04046      14 TKGRAKRQDTENDRHDDLMGSLQILKK-KYPA---LEKTLANGHVFVPLLRgSDANSFDGLISAASGI--SGNYTVVSde 87 
SCU81098      12 TKPNYKLQRPGLLDSASIATVYRGLTRkIQKR-----TPLRNAQLFIPLSA------------TLADIIDETQFSGLQtg 74 
Q6CT52        19 NKKQQTTLVPNKSKTDDLWKVLSNVTEdQSVAqlpIDKKIKYSQVFIKITP-EQRLKLPIFLADLKRALELDTITLYE-- 95  Kluyveromyces l...
Q75DY7        16 LQKKQKYAGEATANTQNIWKCLPRLSE-HEMD---IDNAIKHSRLFIRLSL-EEQKHLRTIITAINDVIDAEKYAFHT-- 88  Eremothecium go...
XP_003646712  16 PTKKHRYNDSASSVRQKIWKCLPRLSE-REMD---IENTIKHSHLFIKLTS-NERDYLQSILKGIKDVIDDSKYTFHS-- 88 
5ZWN_W       105 ----eQKdegmlFYIVLKDFNILDSCFVLSVLLAFQKRLWMAP-SEKSYFRVPKNINLTGSFYLPKNIe------tGRGH 173 Saccharomyces c...
Q6FM44        95 ----gQLy---tHVVILRNFSVLDFCLVVPVLLSAVKRLNS---KTSDYFKFDSHIFCNGTFFVPDNT------------ 152 [Candida] glabrata
XP_002553945  85 ----gNV-----SYLDFSNFSSLQLALVLCSIFGIKSKQWLGK-STSDSRSIPRNIPLRGSFYIHKTC------------ 142
SCU85222      85 ----dGL-----AYICIQDFSALELALALGFILGNKGKRWFAK-ENKDSMVVPRKVPLRGSFYIHKTC------------ 142
CEP62034      85 ----dGV-----SYLCIRNFTALDLALILGFVFADRAKHWVSI-GKDDSSHVPRQVPIRGSFYIHKSC------------ 142
SCW04046      88 ----dGV-----SYFYCSNFNVLDCAFVLTLIFSKSDNRFSKTgSALSFERVPKGTAIRGSFFVYRSCdlsllrynSTAK 158
SCU81098      75 vlqtrKTpdheqAFLSFSNFNPLECAYVLSFLFYNGSRQCAR--DSKDHWTVPKGAHLRGSFYVYKSCdvsp-etsTMKP 151
Q6CT52        96 ------------MFIELKSFTLLEGCVAVTAILNYLHKTGATP-TNVKYWDINSASLLRGTVLVHKSVkva--qteSTSD 160 Kluyveromyces l...
Q75DY7        89 ------------HSIELKNFHITDCCVLLAFIMINLNKLRRGL-GGTDYCSITKPFYLRCSVYIHRTC----------QV 145 Eremothecium go...
XP_003646712  89 ------------ECVELKNFHITDCCVLLPFFMINLNKFWNKS-NDSDSCSITKPFYVRCSVYVFKSC----------QI 145
5ZWN_W       174 IITSYRREQPSSSIVEVGFNVVPDFQQFQV---KACHVSKFMNELSNFFSQVEFGKcEANVINYFKREYNRTYSQISLAL 250 Saccharomyces c...
Q6FM44       153 ---VISIDRTTLQLKETALRLIPGFKELNCtptESNNIQDMINTLANFISKVKFGKnKDDIYATFKRELALFSKRTRFGL 229 [Candida] glabrata
XP_002553945 143 KVPRDHPESLKCGISVSRVVDITNFVEVSI---DIYGATSFIEGLTRFASFLKFQKsENWVKSEFYEGLRNKWLVSEMSI 219
SCU85222     143 -KVNQKTNDIPDGITISKYIQLNDFIEISI---EQYGVGPLMDAIIKLSIGMVFRKsPAQVNCEFSNSLRESKLRSQIAM 218
CEP62034     143 -KDVFETRGPTNGVTIAQFSELSMFTEISV---DRYGIPASFDAVCVLLSKLKFQKsVDRAKQEFQTSLRDLTLKRTITV 218
SCW04046     159 RDVVQEKNLFNTHISVSRVVDIAEFREVSV---MNYGFSRFLHSVVDALKGIKFRWaPVKINNIFAQNFKSYKCSSQMVL 235
SCU81098     152 KKSVLDSARAHYQINVSEVSDVAHFKEVYV---SGLGLLDFMQATMELIERLRFRScPSHLSELFGMKLAEKSSLAAVKI 228
Q6CT52       161 LLFRKASKPRPFKCQLATVCSIQHFKEIYF---EGETIWDWMKGLLNILNEWKFRPvNGSVTELLEHKANHERQRIVSSF 237 Kluyveromyces l...
Q75DY7       146 VQMPTANKKTTFRRQLVRLPAVSAFKQVEF---QSADLKDLMQGILQQVSAWRFRPsPTYLHRDFAAGLILQREQVAKEL 222 Eremothecium go...
XP_003646712 146 LQIPVFNKKTTFHNHLAHVSGVPGFKQIEF---QSADLKDLMGGIVHQISNWKFHPsKTPVHKRFIAALSNQNNVLRSVI 222
5ZWN_W       251 YELPLI-GDGLFDIKSYISKTRPIIETSKAQMIKHISEM--KAYNEISGLQGDQFPRQQRPLSNSPSSNSIsssqtieag 327 Saccharomyces c...
Q6FM44       230 GEVSMLeKGMLIDSQAVIDKNLPLVQNTKAKLQTYVQTL--LDENEDKITTEVQTTAAKSSDAISSTNGNNnvaskpiqs 307 [Candida] glabrata
XP_002553945 220 AAVPFLeRGLLVNNNEIAKTNSALIEKTRKSLEGFAQDL--IKNNNETPMEKRDESEAQGLTSTSISERKSs-------- 289
SCU85222     219 TTVPFLdKNLLIDEDELFKSNGPALQKSQDLLNAYVNSL--REYNEAIPTLEKGDKNASRASPQPVVTKKApa------- 289
CEP62034     219 TSIPFLdRDILMDPTTVSKVNGPIVEESKKALGSFVESV--LKYNEAVPVATKEATDSPKASPQTIRSTRKtt------- 289
SCW04046     236 DEIPFAsEGLLIDRQQILKQNLEAFEKTKSALEQFAKSVlePDEGEENLEKEKARHFAAENSKLQPANPRQ--------- 306
SCU81098     229 NEIPFIaKGLLIDTSDVAKTNADVLEKSRVALNKFAQDLtsTELKSETPALADAKGTSARNAHDNQPNQRKh-------- 300
Q6CT52       238 SELAFL--KGLLDPEFLNRKNKRLIDIDNKELETFMTEL--QQYNEKELTIAAKASKDTKLKNSAAASPTNlrqk----- 308 Kluyveromyces l...
Q75DY7       223 APMSVV--TSLIDMGLVMPQNKAAIEQTQRALEEHGQRL--LLHNEQVTVAAV---DEAKPQTTDSKPSRYsglp----- 290 Eremothecium go...
XP_003646712 223 EELPIY--VNLIDMDLVAKVNIPAIERSKKNMEDYAIKL--QEYNNKVSVKDIKPTDETKTQKDTVKSSKYsnlm----- 293
5ZWN_W       328 atsyqtqpqrhavnkpsnvlnSSNRHSGPKTFEDGRYSEG-------------------NKP--GFMTQDEIKQHCIGTI 386 Saccharomyces c...
Q6FM44       308 r-----------fqnnqshnvPSSRYSHQATSTAIRKPYTakeasplp----tqsraspGRP--RFMTIEEIRGRCIATV 370 [Candida] glabrata
XP_002553945 290 --------------------sNTSRYSVSTHDSATRSTKAgsgrt---------ldpqsRSLnsNFLTQEQITDYCKATI 340
SCU85222     290 -------------------paSTSRYSGTRSVGQSTSRYGmpnggsagnnngrtlnpqsRSLtsNYLTQEQVKEYSIATV 350
CEP62034     290 --------------------pGTSRYSGSNNTDQASARNIparavgtng-ggrtldpqsRGSnaNYLTQEQIKDYCVATV 348
SCW04046     307 ---------------------SSSRLNRGNQPFNKEPTGHt------------------RYTgsSYLTHDEIKEYCVATI 347
SCU81098     301 ---------------------ARTTNQNASNAIPRDTTSH-------------------RGNspGFLSQEQINHYCIATI 340
Q6CT52       309 ------------------avtATSRYKGGNNIPIKVNERRlqhn------------tpsRAPqhSVVSSQDLHRYCIATI 358 Kluyveromyces l...
Q75DY7       291 ------------------tkgPNSRYQGAPARASPHGaf------------------qdRKQnpGFLSMKDITEYCIATI 334 Eremothecium go...
XP_003646712 294 -----------------qqkhTTSRYQGTSKRHTPTPNAMss---------------qdKRTthHYASSEDIKSYCMATI 341
5ZWN_W       387 KASMDAVKKKSSYQILKTYVRCPRQNYIDIVYQNLNDLRSKTNCNIVVLNLNNLHESQMWLESLNTTNYT---IFAQAPH 463 Saccharomyces c...
Q6FM44       371 RASIDSVKKISAYQIVKVYVKFPKKD-SDTLFSNLDELRNKSNCNIVVLHYNNEHESKQWLDGLDLTRYI---RGQDEPN 446 [Candida] glabrata
XP_002553945 341 QASIEAVKSKSPYQIIKTYIKCPRVYYVDLLYEHLNRLRSETNCNIVVLNLNNVHESTSWFGSLKVSKFT---SVSSIPH 417
SCU85222     351 KASIEAVQSKSPYQILKTYIKFPRHDYIDLLYDKLHDMRQETNCNVVVMNLNNVHESTSWFDSLDVAKHMenaKITSVPH 430
CEP62034     349 KASIDAVKSKSPYQILKTYIKCPRQHYVDLIYDNLHDLRAKTNCNAVVMNLNNVHESTAWFNSLDVSKHTkdsKIVSVPH 428
SCW04046     348 HATLEAVKRKSSYQILKTYIKCPRQYYIDIVYDNLNQLRSETNCNIVVLNLNNVHESTSWFDSLDLSKYT----TVSTPH 423
SCU81098     341 KASVDLVKTKSSYQILKTYIKYPRQFYLDLLYDNLDRMRASTNCNIVVLNLSNVHEAGPWLDSLNTSKYT---EVKSSPH 417
Q6CT52       359 KASISKVTEKSAFQIIKSYVKYPRSQ-IDLIYDNLNQIKSKTNCNVVILNLQTIHESNTWFEQLPISVNI-------DPP 430 Kluyveromyces l...
Q75DY7       335 KATMEIVASKSAYQITRVYVKCPKSC-VDVLYQKLADLRTESSCNIVVLNIQTVHESTSWFDTLNMERHT-----TTVPP 408 Eremothecium go...
XP_003646712 342 KATIDVVSSKSAYQITRAYVKYPRTC-IDSLYQKLAELRNESNCNIVILNIQTVHESTAWFENLNTEEYA-----SIVPP 415
5ZWN_W       464 PSTIRVISIGGVGEYIVKALELILNILE 491 Saccharomyces cerevisiae S288C
Q6FM44       447 ASTVRILSIGGVAEYIVTALEGILALLQ 474 [Candida] glabrata
XP_002553945 418 PSTVRVVSIGGIGEHNVKSLQLLLKLFE 445
SCU85222     431 PSTVRVVSIGGIGEHNVKALRLLLDVLN 458
CEP62034     429 PSTVRVVSIGGIGEHNLEALKLLLQLLD 456
SCW04046     424 PSTVKVVSVGGIGEHNLKALQMLLDLIQ 451
SCU81098     418 PNTTRVVSIGGIGEHIVQALQMLLELLN 445
Q6CT52       431 PSATRVISVGGVGGKCKVALEMILTLLE 458 Kluyveromyces lactis
Q75DY7       409 PSTLRVISIGGIGENCKKALLLLQKFLE 436 Eremothecium gossypii
XP_003646712 416 PSAVRVISIGGVGENCKRALRLLQNFLE 443
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