Conserved Protein Domain Family
DNA_pol_D_N

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pfam18018: DNA_pol_D_N 
DNA polymerase delta subunit OB-fold domain
The eukaryotic DNA polymerase delta (Pol delta) participates in genome replication, homologous recombination, DNA repair and damage tolerance. Human Pol delta consists of four subunits: p125, p50, p66 and p12. The first three subunits correspond to the three subunits of S. cerevisiae Pol delta. p50 serves as a scaffold for the assembly of Pol delta by interacting simultaneously with all of the other three subunits. This entry corresponds to the OB fold domain found in the p50 subunit.
Statistics
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PSSM-Id: 436215
Aligned: 78 rows
Threshold Bit Score: 81.8615
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014570241  73 QYANIYFIRLTQLVPRVLARARRRWlles---pgnsP---Rakkskiksdaedsqfnrfttelllhqngnsdygtqsstt 146
KXN69961      55 QFLKLYNYRLEILKPICSELAKEKW-----------SkkyEni------------------------------------- 86 
EHY65083       5 QYSTVYNKRWHAQSQGLIEHSKENA-----------H------------------------------------------- 30 
Q8SQN5        11 QFNRTYDARLMELRPYIIRSAKASG-----------Tt-pV--------------------------------------- 39  Encephalitozoon...
EJW03455      25 QYNKIYIARLKNITPVITVKILNDHkydnc-fiadiE---Sstdftlhpe------------------------------ 70 
EPR78803       7 QYYKNYRHRLAAIRPIILNNIENNTdkysfpiisslAe-iN--------------------------------------- 46 
ELQ75034      10 QYNQTYVTRLEKMRSLINLDVHDDT-----------T---I--------------------------------------- 36 
KKO75259      11 QYNNTYKIRLVTLRPLISKPQSIDI------------------------------------------------------- 35 
XP_007604536   9 QYNISYITRYNRMRELIMSNPSISE-----------Ys-lP--------------------------------------- 37 
EED43748      14 QYNENYQYRFKVLSNYIFLPKNIDi---------------P--------------------------------------- 39 
XP_014570241 147 rgkqdsrtlqedaemdgleqdespepdyeedvkprmnrrngakkqngsgarstskiVNRVLEVQRD---ELCIVAGTIYV 223
KXN69961      87 ------------------------------------------------------asPDNVMGAQ-D---DINYIVGTIYC 108
EHY65083      31 ----------------------------------------------------------HFCGYLTS---GKIFLVGTLEI 49 
Q8SQN5        40 --------------------------------------------------------LDAILDIEMGrggERCVIVGTLFI 63  Encephalitozoon...
EJW03455      71 ------------------------------------------------nkiaksnkNRNIEALKNDn-rKNLIIIGVFFL 101
EPR78803      47 --------------------------------------------------------TTNIHGNSEQs-nNNFIFVGVLFI 69 
ELQ75034      37 --------------------------------------------------------LSNLSEASSAs--GPVAFIALLYV 58 
KKO75259      36 --------------------------------------------------------CNRIHDLNKQt--EKCFIIGILFI 57 
XP_007604536  38 --------------------------------------------------------LKKLGD---Di-fEECIVIAILVL 57 
EED43748      40 --------------------------------------------------------IKKIGKVN-T---ELCMIKAILFI 59 
XP_014570241 224 EMKLKPSVLDEIA------------------------IDYSIPAAPPRKYVT---PgVDEVLLED-SSGRIRLI---GT- 271
KXN69961     109 KSALKPSIIDQVQe-----------------------NLYVVNPPKVDHYYC---D-SEEYSLED-DSGRIQLT---CS- 156
EHY65083      50 SYPKK-KVIASYSkvsreiranpieneyyeecanksvINNLQKEEERSNMLGcllE-NAEYFLESpNLERIKLI---IS- 123
Q8SQN5        64 ASDLKPTIFDRIDr-----------------------KSKKIKEIEAKTYHS---Q-EVKYFLED-GSGKIELEfldMK- 114 Encephalitozoon...
EJW03455     102 HSCEKPNVFDEMK------------------------PLYDEFAKPLYTYYG---E-NVKYFIED-LKGRIEIK---LSd 149
EPR78803      70 AA-TKPSVFFELKk-----------------------IN-----NSFEVY-----T-NKIYYVED-EHTKVEVI---FE- 109
ELQ75034      59 DCANKETIFDEAG--------------------------LIKKEKNVKPY-----E-NFTYFVED-ESCRVEVI---FE- 101
KKO75259      58 SSDLKTTIFDKLN------------------------TNKKKVEFKKSTYIS---K-DIKYFVED-ETGRIEIM---LN- 104
XP_007604536  58 DSKLKFSILQMND-------------------------------PNVESYV----P-NSQLYIED-FSGKLPIV---FSq 97 
EED43748      60 KSNIKSSIFNTINq-----------------------VSNKKNNNTKEVYIN---S-DTKYFIED-DDCTIDIN---FIc 108
XP_014570241 272 --GIEQGKwaLV--TGIIVSVLGAETATGDFEVLDL 303
KXN69961     157 --DWNKFPp-LI--TGVVAAILGRKIPDGSFDVEDI 187
EHY65083     124 --DEASEY--LV--DGVVIGVLGEKNDENHFVVDTI 153
Q8SQN5       115 --AVYRKH--FVisTGMCIGVTGRMAEKGRFLAEDV 146 Encephalitozoon cuniculi
EJW03455     150 kcLMEYPL--LV--TGMVLGFVGFFDSLNIFCVNDI 181
EPR78803     110 --ENYHEI--LC--TGMVLGFIASESENGIIKVKDI 139
ELQ75034     102 ----PKDL--FV--TGQVLGFIAERN-THSLTIKSV 128
KKO75259     105 --SKQKDF--LC--TGMCLGFIGNLK-NNIFNVEEI 133
XP_007604536  98 -sFNKLSL--LC--TGTVLGFVGCKIETNVFVCTDV 128
EED43748     109 --DLYNNY--LI--TGMVLGFIGRC-ENGIFNCTQI 137
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