Conserved Protein Domain Family
Carm_PH

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pfam17888: Carm_PH 
Carmil pleckstrin homology domain
This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.
Statistics
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PSSM-Id: 436119
Aligned: 14 rows
Threshold Bit Score: 119.695
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
VDN50271       20 CRLVCSVEYGSKPeKFESRLFAVSKFRIFILHGKTPIslKIDRFIHILSIRAIHLINDNEVFVIKSLIN-SVGKRrifiR 98  
XP_027321735   25 ILLVKSVQLQVKS-KYDDFILVLTPWRAYVVPAMLPV--RVHSSFSFLEVRDIAVREPSVVVIETDTSP-YSFRL----M 96  
XP_015223909   26 IKFMWRVQQNHSRaKADERILVMTLWRAYVFHNRLPA--KVESSFSYLEIYAITIGNFNQAAIETDRLC-YSLTL----M 98  
KFO33855       25 IAVKKKVKLEVKGdKVENKVLVLTSCRAFLVTARIPT--KLELTFSYLEIHGVVCTKPAQMVVETEKCN-ISMKM----A 97  
XP_014462218   26 ISVKKKVKLETKGdKVDNRILVLASCRAFLLTSRIPT--KLELTFSYLEIQGITSSKPGQLIVEMEKCN-ISMKM----A 98  
EZA60295       25 ILLKNVVKLETKQdKQENRVLVFSPCRLFLLSAKVPT--RIDCHFHYLEITAIESRRANQLCLTVGERF-YNFTTtnqgA 101 
KDR15295       25 ILLKNVVKLETKGdKTENRVLVFSPCRLFLLTAKVPT--RIDFHFHYLEIQAIESKKPNQLSLTVGDKV-YSFLTgd-eT 100 
XP_026692587  175 VTLKKMVKLERGNvAVDPKVLVLTPYRFQILSTKAPF--KMEADIHFLEIKALDSPTPERLIVTTDTGKiYFMQM----I 248 
XP_007550849   31 IKFICSIKLDTKNgKTEDRILVLATWRLYFLAPKIPA--KVETTFNFLEIRALNSHPDHQVIIDTDKTG-YTLRF----E 103 
XP_016854030   28 IHLLVRVKLETKPkKNEDRVLALTTWRIYLFALKVPA--KVECSFNVLEIRALNALNHHQILVETEKAN-YSLKF----P 100 
VDN50271       99 SEIPSHDFVCHILSAIKHYFP 119 
XP_027321735   97 SFDDVEQVVIHVTMSLKKVFP 117 
XP_015223909   99 SLEELEHMVSHITASLKKIFP 119 
KFO33855       98 SPEDVSDVLGHIGTCLRKIFP 118 
XP_014462218   99 SSEDVNEVLAHIGTCLRKIFP 119 
EZA60295      102 DTTEVDAMIEALHTAIRNIFP 122 
KDR15295      101 GSQEVDAMVLALATAIRNIFP 121 
XP_026692587  249 GTDDADHIIGRVALSLRTIFP 269 
XP_007550849  104 SREHLNHVVSHINFALSRIFN 124 
XP_016854030  101 NPESADQVTRHVNTALAKIFP 121 
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