Conserved Protein Domain Family
FOXO-TAD
?
pfam16676: FOXO-TAD 
Transactivation domain of FOXO protein family
TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.
Links
?
Statistics
?
PSSM-Id: 435506
Aligned: 17 rows
Threshold Bit Score: 62.3513
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_015789420 552 PLPNDLDLNMdsLQGGLECDVDQVIRHELSVE-GNLDFNFESM 593
CAF90649     477 RLPADLDIDM--FNGSLDCDVESILLHDIMNSgEELDFNFDSS 517
NP_001128604 641 RLQSELEMDV--HQSSLDCDVESILLNDFMDStEGMDFNFDGS 681
XP_015204154 574 RLPADLDLDI--FHGSLDCDVESILLNDFMDS-EEMDFNFDCA 613
CAF95479     335 RFPTDLDLDI--FNSSLECDMDSIIRNELMDT-DGLDFNFDSl 374
XP_005477409 553 RFSADLDLEV--FSSNLDCDMDSIIRNELMDA-DCLDLSFDSR 592
XP_014324429 562 RLPTDLDIDM--FTENLDCDVDYIINSDLMDG-DGMDFNFDPI 601
ELK15655     466 KMPQDLDLDM--YLENLECDMDNII-SDLMNGgEGLDFNFEPG 505
PKU26746     186 RLPIDLDIDM--YMENLECDMDYIINSELMDG-EGLDFNFEPm 225
XP_007255737 586 RFPSDLDLDM--FNGSLDCDVDSIIRSDLMDS-DGLDFNFDAl 625
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap