Conserved Protein Domain Family
TMF_TATA_bd
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pfam12325: TMF_TATA_bd 
TATA element modulatory factor 1 TATA binding
This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes. The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most conserved part of the TMFs. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organization in animal and plant cells. The Rab6-binding domain appears to be the same region as this C-terminal family.
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Statistics
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PSSM-Id: 432481
Aligned: 77 rows
Threshold Bit Score: 84.5191
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012741277 726 SVSTAGAGPSVQLVERMSAAVRRLENEKISTKEELVRLASQRDEARAEIVSLMQEVEAKRADHNRVLELEKEVDAINARY 805
XP_003957720 491 SNSNNIDSGTTQIVTRLGAEIRRLEGELKSIQDRYNNLSHEKSNANEEILRLMNENGQYQSLKEENENLQLRINELNHKL 570
EEQ38137     688 lpafSSGANNIQLINKMSSTIRRLEIELMSIREENEALTKEKNEAQQEILGKYEVEARVQELESSMTKLSQELEQKSKKE 767
XP_001485677 619 LSLTLSGGNNIQLINKMSSTIRRLEIELVTIREESAQLAEEKEQLQQELLTKIKLSNENDSLKEEIANLQLQLAEKDDQA 698
CCE42260     575 vptsLSNSNNLQLIHKMSSNIRRLEIELNTLKDEYEKLLDVKELREQELLESIKVYEQVNELKSKIEELEKIIEEKNAKE 654
EDK44788     707 ipSTQTTNNNLQLVNKMSSNIRRLEIELHTLKDECTKLLDEKEQREQELLESIKLNDEVNELKEKIAELEKTIQEKSIKE 786
XP_007376650 678 NIPTSSHSNNIQLVNKMSSTIRRLEIELNTLKDEYSKLSMDKEKLEQELFESLKLNDEMSQMNVQIDELKKQISEKDRKE 757
EMG49061     578 vppTSLQNNNIQLVNKMSSTIRRLEIELNTLKDEYSKMSEEKDTVEQEYLETLKLNDEVKSLQSQIDGLNQTIKEKETKE 657
Q5ADY0       537 gVPASSHSNNIQLVNKMSSNIRRLEIELNTLKDEYSKISTEKEKVEQELLESLKLTDEIKLLHSELDSLKSVIKDKEIQE 616 Candida albicans
EER30584     550 niPTSSHSNNIQLVNKMSSNIRRLEIELNTLKEEYNKVSEAKEEVEQELLESIKLNDEVKGLQEEIKHLQQVINSNENKE 629

XP_012741277 806 QTTLEMLGEKSEMVEELKADVQDVKAMYRELVENT 840
XP_003957720 571 EASLQVLGEKAEQNQELENDVSDLKEMLHLQVQQM 605
EEQ38137     768 ETLLEVIGEKSERVAELQADVEDLKDLCRQQVQQM 802
XP_001485677 699 QTMLELIGEKSERVAELEADVEDLRGLCKLQVQQM 733
CCE42260     655 STMLELIGEKSEQVEELKADVADLKDLCRNQVQQM 689
EDK44788     787 QTMLELIGEKSEQVEELKADVVDLKDLCRSQVQQM 821
XP_007376650 758 QTMLELIGEKSEQVEELKADVFDLKELCKLQVQQM 792
EMG49061     658 QTMLELIGEKSEQVEELRADVVDLKELMKLQVQQM 692
Q5ADY0       617 QRMLELIGEKSEQVEELKADVVDLKELCKLQVQQL 651 Candida albicans
EER30584     630 QTMLELIGEKSEQVEELKADIVDLKELLKLQVQQL 664
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