Conserved Protein Domain Family
POP1

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pfam06978: POP1 
Ribonucleases P/MRP protein subunit POP1
This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.
Statistics
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PSSM-Id: 429227
Aligned: 71 rows
Threshold Bit Score: 112.368
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCE66155       57 FVNTRAFEIKQLYSSMHQS-RRSNATRVFQSLPRKLRRRTASHNIARIPKRMRNRAKRE--------------------- 114 
XP_002175674   43 FLSARSFEIRAFQDAMKRS-KDSSSQRAFQSLPRCLRRRAASHNVRRIPKALRQRALYE--------------------- 100 
EGX53980       63 FVNSREYEIRSLLRSMNSS-KNAQRKRAFQSLPRELRRRTAAHNPSRAPKRVRETARKE--------------------- 120 
EPS40528       72 FVSSREYEIKSLLRSMNSS-KNAQRKRAFQNLPRDLRRRTAAHSAKRVPKRVRATARLE--------------------- 129 
EMR11464       52 LVNSRKFEIRSLFEAMRCS-RQLSAQRAFQSLPRFLRRRSASHDFKRVPKYLRIRAKNE--------------------- 109 
KJE94664       64 FAAARAREIQTMLHALNEPvNGGGGRRVFQTLPRHMRRRAMSHNVKRVPKRSRSAAQREteaiarggggqqannagdgls 143 
Q5CUH4         30 LSSGRKDEICRYVNFIKKS---NSTKRCFQRLPPAIRRRSMSYNVYRAPRKIRPTLFYE--------------------- 85   Cryptosporidi...
EEA07190       34 LVQGREKEICKFLSFVQET---HSIKRSFQRLPPNLRRRAMSYNPYRAPQRIRARLIYE--------------------- 89  
EPE04517       56 FLSSLEQEVGDLHSAIKHS-RDARVEKAFQRIPRSMRRRTASHNARRLPRRLRKQAHRD--------------------- 113 
ERS98367       33 FISALEQEIGDLHSTIKHR-RDDRVEKAYQRVPRDMRRRTASHNARRVPRRLRQQARRA--------------------- 90  
CCE66155      115 -------MNKNNnnnekvnnisgGLTIAAKKRSK---KSLNA------KQFYRAKMSIKLLRLFTKTKNLKmLSGPkelt 178 
XP_002175674  101 -------MSLQS-----------STTKAIEPSRL---RFKRY------VRRLQKRISA-----AGKSKQIVsAGTL---- 144 
EGX53980      121 -------LTEDN-----------------TTVRK---KRRDY------CPSARRLNANQLRILSLRNNNSMiPKAV---- 163 
EPS40528      130 -------LVGDN-----------------TAPSR---KRRDY------RPETRRLNVAQLRMLS--NTSTFaP------- 167 
EMR11464      110 -------MKNKN-----------T-------LKK---KGIKG------KKRMRLLTVHKLKKFGVRNVSVSeESKD---- 151 
KJE94664      144 akglpvaMAAES-----------ATTVRVDKIQRetgRSVSKr----aRKRIYARIRRTIQAVKRPTRMRRrIAA----- 203 
Q5CUH4         86 -------MAK-------------APPRISRKRRKerkKLPWI------RRNLLLRAINRENFC----------------- 122  Cryptosporidi...
EEA07190       90 -------MKK-------------APPKPSRRAKKdrrRIFTF------SEKYKMRNRNHNLRL----------------- 126 
EPE04517      114 -------QAADN-----------TPSIATGLAKRkktRPASAwvyentKKRIKLQEEKKLAAQgmge------------- 162 
ERS98367       91 -------HAADN-----------TPTVASGLAKRkkaWPASAwvhentKKRIKLQQEKKLARGaggg------------- 139 
CCE66155      179 lrnittrqkikhfkdilknklPSss-----taIACNNQMGSYDNTAVDSL-ATK-TYSRIKYLKRQ------KHFKWLST 245 
XP_002175674  145 ------------------------------------QTKHTTEDSRIPSL-PLV-RLVKGQFAQRQ------LRKIWLPT 180 
EGX53980      164 -----------------------------------PGSRQTATRGLGRTR-SYI-GSKSSRYRKRQ------RHKTWLPT 200 
EPS40528      168 --------------------------------------RGGNSGSWGKIS-SQI-ASRSSRYRKRQ------RHKTWLPT 201 
EMR11464      152 -----------------------------------------ELDESKDDF-LKV-KKVKGKFYKRQ------KDKTWLPT 182 
KJE94664      204 -------------------------------------------------------NARHRHLLKRA------RAKGWLET 222 
Q5CUH4        123 ----------------------------------------GKEILPFNIR-NSSdLSTAFRKKGQRstklpfNQFKWMES 161  Cryptosporidi...
EEA07190      127 ----------------------------------------DIDRIPEVVNlANYnTTDNAKYSKHWdintqiNQYKWLES 166 
EPE04517      163 ----------------------------ddeeMDVDDVGTDDDAEGGASLtAVPrTPLPIKNLR-------------LPT 201 
ERS98367      140 ------------------ggdDVndvveeeeeGGAEEDGAEHDKDEAAVM-ACPhPPIAIKNLR-------------LPT 187 
CCE66155      246 HIWHAKRSHLIKR---WGYQIPYSPTQKCYKLTHRigssVASSDGNLL--QDTSFIGNMIIQNE 304 
XP_002175674  181 HLWTSKRAHMVNK---WGYAIPQRPTAKSYRPTHR----AAFTEEAIA--FDMSYEPIFAITAP 235 
EGX53980      201 HIWCAKRARMVLK---WGFSLVETPNLKCYRPTYR----AATRDACIA--IDTSYYATILLVGR 255 
EPS40528      202 HIWTAKRAHMVTK---WGFVLADTPTLKCYRPTYR----AATRGGCMA--FDTSYYATVVIEGR 256 
EMR11464      183 HLWHVKRAKMLTK---WSYSIAKTPTEKSYRPTHK----FANTSGAVA--FDTSYFCTICLWGE 237 
KJE94664      223 HVWHAKRMKMADQ---WGFRLALRSAQRGMRATHR-----ATLHSVTA--HDASYHGIIELAGP 276 
Q5CUH4        162 HLYHSKRFKMCDA---FGYKLPICSTSKRNRKIYR-----AFKHEFVV--HDSSYLQLFELNGV 215  Cryptosporidium parvum
EEA07190      167 HMYFSKRFFMFEA---FGYKLALCSTAKRRRKLYR-----QLSHNCIV--HDMSYFHLYELRGE 220 
EPE04517      202 HRWHAKRAQMDNPgylWNSTIVRTSANKTYRMTLR----ASGLRPAMCvsWDTSYKATIYLRGT 261 
ERS98367      188 HRWQAKRAQMDNPgflWNTTLVRTPANKTYRMSLR----AAGLKPGMCtcWDTSYKPTIELRGP 247 
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