Conserved Protein Domain Family
Moulting_cycle

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pfam04870: Moulting_cycle 
Moulting cycle
This family of proteins plays a role in the moulting cycle of nematodes, which involves the synthesis of a new collagen-rich cuticle underneath the existing cuticle and the subsequent removal of the old cuticle.
Statistics
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PSSM-Id: 428165
Aligned: 21 rows
Threshold Bit Score: 350.122
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003114588  165 PFTLITKQITKSIRALKNK--KEERGWRQIMVDVKKTGEVIEKRRKVKEMIGKSVRSRSAKPKKlylsprkplanndyea 242 
4_pfamImport    1 PFTKITKQITKTIRALKNK--KDERGWRQIMVDVKRTGDLVEKRNKVKEMIGKSVRGRTRSnarkp-------------- 64  
O76555        187 gmTKLAKSLTNTVRAMKNKt-ERAEPWVEAVGRIKKLGEEAKREKKNREVMKKRLKQMIDNTPAefvdpr---------- 255  Caenorhabditi...
XP_001895950  187 PFGILGKHLSKMTRIIKNK--EPNSSWKKTMYEIESLKRREQEKNDFAEKLKKRFPFSFKNTEPkltpe----------- 253 
XP_002636127 1036 PFSNIAKHLTNLVREKKNKenEPKKKWQTVINEIKEELDRIKKKKKDREEFKNIFSKYSRTMKMlgld------------ 1103
Q9N511        209 PLALIARKLTELVRAGKNKk-EPQKRWQDVIQEIKNESTRIKGKSQNKERMKRKFSKFIRTMKGtgln------------ 275  Caenorhabditi...
Q9XU60          3 PLGVLAKHLSHTLRLIKNK--RTTSKWEDTISRISEKASQIKQQKDMERRIRKQRGY----------------------- 57   Caenorhabditi...
XP_003091210  177 PLGVLAKHLSHTLRVIKNK--RTTSKWGDTITRISEKAQKIKERKEMQRLLEKRMNVFTENGE----------------- 237 
EGT56201      176 PLGVLAKHLSHTLRLIKNK--RTTSRWEDTITRISEKAQKIKERKELEKLFQKRMNVFQEASE----------------- 236 
XP_045092810    2 rIHLLAKHLSHTLRIIKNK--RNTSKWEDTITRISEKAQKIKKRKEMEKMFQKRMNVFTEAAEGl--------------- 64  
XP_003114588  243 lddpiqMTNEIiqtSSESDKKIDAeELLKRFQD-----HPEDILNDDAQGLLNMTGQ-ETEAVLRIKLIRE--------- 307 
4_pfamImport   65 -ladnnTSDEQlenDS---KPVNMdEMFQRLQD-----HPEEILKNDAPRLLNMTGE-QSEAVGRIKLIRD--------- 125 
O76555        256 ---------------------------------kpvalKQAEMEDENNEIAKLMRKKeADEIRVPLKFLRK--------- 293  Caenorhabditi...
XP_001895950  254 ---------------------------------ekllaKELHISNHLLQGLDKNSMK-TKKTLEIIQLFKR--------- 290 
XP_002636127 1104 ---pkqAFEKAvsfFLQCRTRIPNfDIIQGMSS-----LGEEIAD-SSNTTEPMSEE-ETALKKPLMMIRDgkfrvldfe 1173
Q9N511        276 ---pdkAMQSI--------------GMEDLFADep--iLSEKEQD-AKDAKEMMSPD-DKILNEPIKLIRQ--------- 325  Caenorhabditi...
Q9XU60         58 --------------ELPEEKPVPLdKDVRELIDlekyiGDEDLKSMVRHKSGNLTEQ-DRAMLIPMRLIRG--------- 113  Caenorhabditi...
XP_003091210  238 --------------NFEQLKS-PEdDEAKELIDlekyiDDDDLKSMVRKKAGNLTEQ-DRMMLIPMKLIRE--------- 292 
EGT56201      237 --------------DMKQ--SRILdHDAQELLDlekyiGDDDLKSMVRKKAGNLTEH-HRMMLIPMRLIRQ--------- 290 
XP_045092810   65 ---------------------nPNdSDAQELMDlekyiRDDNLKSMVHKKAGNLTDQ-DRMMLIPMRLIRG--------- 113 
XP_003114588  308 -----AVKLGLSLGG--QNVSGFDQKSMKFASPRFFAIAPEEHKKENDTvsfireqdtceltcsfsqINILSPSLFSLHD 380 
4_pfamImport  126 -----AVKLGLSLGG--QNVRGFDQKSLRFASPRFFAIAPEEHKRKDDT------------------VNILSPSLFSLHD 180 
O76555        294 -----AVKTALMLGG--QNVTDFDQKTLKMVSPRMMSIVPE--QEDESL------------------FNLLSPSLFSLHD 346  Caenorhabditi...
XP_001895950  291 -----AIKLAMVLNG--ANGTKLENKTLRFGSPRLLSLVPD---NVNDQ------------------INILSPSLLSMHD 342 
XP_002636127 1174 nkkssGVKLGMMLAG--KNVSNFDERKISLMSPQFMSVLPD--EQANDT------------------VNLLSPSVFALHE 1231
Q9N511        326 -----AIKIGMMAAGktKDAEAMSDKKIALLSPQFMSILPD--EVANNT------------------ISLLSPSILSLHG 380  Caenorhabditi...
Q9XU60        114 -----AAKLGLSMTG--YNTTDFDRKVVRIFSPKLMSVVPESEEARKNE------------------IDILSPSLFSLHD 168  Caenorhabditi...
XP_003091210  293 -----AAKLGLSMTG--YNTTDFDRKVVRIFSPKMMSVIPTSDETKKDE------------------IDILSPSLFSLHH 347 
EGT56201      291 -----AAKLGLTMTG--QNTTDFDRKVVRIFSPKMMSVVPTSDDAKKDE------------------IDILSPSLFSLHQ 345 
XP_045092810  114 -----AAKLGLTMAG--QNTTDFDRKVVRIFSPKMMSVVPANEDEKKDEvgagysn----pytinfqIDILSPSLFSLHH 182 
XP_003114588  381 EGSPDEQKTSLVKLLGDK----EGIDKDSFMDLLTELTGVADTVDDAAQKASRE-----SEGTLINVKGEEINVSRENL- 450 
4_pfamImport  181 EGTQEEKSLSLPKIFDNTitqhDGAEKDSFMDLITEISGVADAVDDAAQKVARE-----SEGVLMKSDGAEISVSRENV- 254 
O76555        347 EGEGIEKLTSLPHLLKKL----DNHGQNAWMDFIVEAAGVSDEVTKTEKVFREK-----KEKELRGTDGVPLYFTKENA- 416  Caenorhabditi...
XP_001895950  343 KGKGLEALTSVPELLKAA----GNRDYEEWLSFIIEASGTTDAIHKLKEKNELDwlppgYKSMPRGIDGQPMFFTKENV- 417 
XP_002636127 1232 KGTELDQMLSLSKAMRFL----SENGHDEWMNLILEASGVTEAVEKMRVRNRREe-------------------TRNRVv 1288
Q9N511        381 EGSDLDRQISLTKALKLL----ESTGQEEWMNFVLEASGVTETVANLRKAEKEEee-keRMRDFVDKDGKPMYFSKENA- 454  Caenorhabditi...
Q9XU60        169 DGTADEKEVSLQNLLGSLs---TNKDTSQLLDFIIEATGVDEAMERVETKIDE------SFGSERGPEGQPLYFTKENV- 238  Caenorhabditi...
XP_003091210  348 DGSEIEKEVSLQNLLGSLt---AHKDTSDLLDFIIEATGVDEAMERVETKIEE------SFHSERGPEGQPLYFTKENV- 417 
EGT56201      346 DGSSIEKEVSLQNLLGSLt---ANKDTSDLLDFIIEATGVDEAMERVESKIEQ------SFQQERGPEGQPLYFTKENV- 415 
XP_045092810  183 DGSEIEKEVSLQNLLGSLt---ANKDTSDLLDFITEATGVDEAMERVEQKIEQ------NFQSERGPEGQPLYFTKENV- 252 
XP_003114588  451 --TKVYGEeNYRKMKVLEKLHGMYTDE---------------QvsmMNHFNKSGYAIMTDKQRDMVYGSGAPFENKLTLE 513 
4_pfamImport  255 --TRIYGEdNYRKMKVLEKMHGMYTEE---------------Q---MHHFNKSGYAIMNDKQREMMYGAGAPFENAQTMK 314 
O76555        417 --TKILGNeEKSKIEVFEDLDKSYSEE---------------Q---KKKLNDDGFAFLTEKQMERLYGKESPYKHTKALK 476  Caenorhabditi...
XP_001895950  418 --TEFDPE-LAREVELFENLTHSLTPK---------------Q---LTDFNTTGFSMMTPKQLTMFYGPQSPLNDSKALN 476 
XP_002636127 1289 pkXXXXGEyETSKIDSMEALHKSMSAAqvlyrnwqlswsllfQ---MHEMNTTGFAIMTPFQISQFYGPRSPYNDSYAYK 1365
Q9N511        455 --TQIYGEyEAGKLELLDGFYKSLSSG---------------Q---MESMNKTGYTVMNDKQLETIYGHGSPFNNSEALQ 514  Caenorhabditi...
Q9XU60        239 --TANYPH-EAQKLEIFEALDRTYSTS---------------Q---LNEMNRTGYAIMRHDQMDLIYGDQSIAKNPKFLK 297  Caenorhabditi...
XP_003091210  418 --TAQ----ESKRIEIFEALDTTYSEN---------------Q---LKEMNRTGYTIMTHEQMDLVYGNYSIMENQKLLR 473 
EGT56201      416 --TEKYPH-EAKKIEIFEALDKTYSEE---------------Q---LKEMNRTGYTIMRHDQMDLIYGNKSVMRNLEFLE 474 
XP_045092810  253 --TEKYPL-EARKIETFELLDKTFSME---------------Q---LREMNRTGYTIMRHDQMELIYGNNSVHKNPEFLN 311 
XP_003114588  514 AGRNLTMPKAKKALHTVIQEIGKGNIKV 541 
4_pfamImport  315 AGQNLTMARAKRALHTVIHEIGKGNIK- 341 
O76555        477 KFKRL-RDDPEKYIEKDIRALAEAEkfr 503  Caenorhabditis elegans
XP_001895950  477 FFLSLSEDDMHRHILSDIRDMAKMNssl 504 
XP_002636127 1366 NYRNIRRNDIPHMLENNIHRMAREEQAF 1393
Q9N511        515 KFRGISPESMPARIEENIRMIAREEMKF 542  Caenorhabditis elegans
Q9XU60        298 QAKALSRAEIDRSIMSTIKDLAKEKVKF 325  Caenorhabditis elegans
XP_003091210  474 EAKRMSRPEIDRSIMQTIDDLAKEKVKF 501 
EGT56201      475 RAKQLSRSEIDRNIMGTINDLAREKVKF 502 
XP_045092810  312 RVKGMSRSEIDRNIMGTIGDLAKEKIKF 339 
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