4C8P


Conserved Protein Domain Family
ZNRF_3_ecto
?
pfam18212: ZNRF_3_ecto 
ZNRF-3 Ectodomain
This domain is found in ZNRF-3 protein present in Danio rerio. ZNRF-3 is a transmembrane E3 ubiquitin ligase that antagonizes Wnt signalling, the signalling system used to mediate Rspo protein actions. ZNFR3 and RNF43, alongside the Rspo proteins, have emerged as a system with therapeutic potential for a number of pathological processes. This domain is known as the ectodomain.
Links
?
Statistics
?
PSSM-Id: 408039
Aligned: 6 rows
Threshold Bit Score: 181.927
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4C8P_A        49 MHPLGLCNNNDEEdLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQgsEDPLKRPV 128
KFO77057      80 SHPLSLCNTSEDE-HTESGFITIVKLEQPDRDPNPCLSLANKAKLAGERGARAILFDITDDESAADQLRK--PRGLSQPV 156
1_pfamImport   1 LHPLSLCDISDDG-LYEYGWVGLVELEPSYLEPVSCSSVYDKAKRALDKGATAVIFDITKRPDAVFQLNSevHATLDRPI 79 
XP_014324913  71 YHPVSLCNTSEDE-RQDSGFITIVKLEQLG---PHCSPLLDKARIALERGAQAVIFDVSDVAIADAELKN--TDSLPHPV 144
XP_022521547  80 SHPLSLCNTSEDE-RQDSLFISIVKLESPESKVPQCQPLLDKARLALQRGAQAVIFDISDDASAANELRD--SGSLLRPV 156
XP_007973468   1 MHPLGLCNNNDEEdLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQgsEDPLKRPV 80 

4C8P_A       129 VYVKGADAIKLMNIVNKQKVARARIQH 155
KFO77057     157 VLIRGHDAELLMGVVNKNREAHVKIEV 183
1_pfamImport  80 ILIEGSAAYQLAKIMRNKQVARVRIQT 106
XP_014324913 145 VLIKGADAKKLMNLVNHNEEATVVIEA 171
XP_022521547 157 VLVKATDAEELMLLVNKNEEAMVEINI 183
XP_007973468  81 VYVKGADAIKLMNIVNKQKVARARIQH 107
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap