Conserved Protein Domain Family
US22

?
pfam02393: US22 
US22 like
US22 proteins have been found across many animal DNA viruses and some vertebrates. The name sake of this family US22 is an early nuclear protein that is secreted from cells. The US22 family may have a role in virus replication and pathogenesis. Domain analysis showed that US22 proteins usually contain two copies of conserved modules which is homologous to several other families like SMI1 and SYD (commonly called SUKH superfamily). Bacterial operon analysis revealed that all bacterial SUKH members function as immunity proteins against various toxins. Thus US22 family is predicted to counter diverse anti-viral responses by interacting with specific host proteins.
Statistics
?
PSSM-Id: 396802
Aligned: 36 rows
Threshold Bit Score: 58.5292
Created: 21-Mar-2022
Updated: 13-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ACM48120     274 AEEATALGRELRRRWAGTTVALQTPGRRlqpmvllg-awqelaqYEPFASAPhpASLLTAVRRHLNqRLCCGWlalgavl 352
XP_002596897 157 AYKSPKKLKAFFQEYRKTTLAVGSNGER----------------FTPWKGGS--SDMARFRLLECS-FGYVNP------- 210
ADD39097      17 RAGDFNGLNDFLEQECGTRLHV--AWPErcfiql-----rsrsaLGPFVGKM--GTVCSQGA-----YVCCQE------- 75 
ACM48019      55 VRRDYEGLRRYLRRFEGSCVSLGWPSqci-------------yvVGG-EHSP--HSLTEIDLEHCQ-NDFFGE------- 110
P16767       157 YRGDVESLSAEVTKRGYASYTIDDPFdecpdthf--afwthnteVMKFKETS--FSVVRAGGSIQTmELMIRT------- 225 Human herpesvir...
ACM48031     265 LARDLLALWRLCMKREGSIF----SWRDgne----------altTVVLNGSQ--TYEDPAHGNWLK-ETCSLN------- 320
AKI14898     202 DPTDAAAVAKTAREMSGLNLVIRTPGRTevepllmlgsieglraCRPFDHMS--AADFRDLLNFIRqRLCCEW------- 272
ADD39174     180 HGHDADALAACVGEHHGRDVNFHTPGRHaktlkllt-sfgcltdCWPFEVAP--AARLAECEMYVTlQLRCRW------- 249
F5H991       202 HDNSISELQRVTCRYRGECVPLRTPGEMtrplllcg-qaenlkgVWPFICME--TEQFNDLLKFFVdRLCCET------- 271 Human herpesvir...
AMJ53521     201 NDTTPEGSYATAERILGCDVKLHTPG-YgtvimrlmktvqqlhrIWPF--CA--LTEVESRRWWWAvRANLAT------- 268 Human betaherpe...
ACM48120     353 parwlgcaagpatmtagttamatgttlpagasgteteaaggdapcaiagavgsavtlppqpygaaggsavCVPnadtHA- 431
XP_002596897 211 ----------------------------------------------------------------------PEK----LI- 215
ADD39097      76 ------------------------------------------------------------------------Y----LH- 78 
ACM48019     111 ----------------------------------------------------------------------FRA----LH- 115
P16767       226 ----------------------------------------------------------------------VPR----ITc 231 Human herpesvir...
ACM48031     321 ----------------------------------------------------------------------VLQ----VF- 325
AKI14898     273 ------------------------------------------------------------------------------Y- 273
ADD39174     250 ------------------------------------------------------------------------------Y- 250
F5H991       272 ------------------------------------------------------------------------------M- 272 Human herpesvir...
AMJ53521     269 ------------------------------------------------------------------------P----WY- 271 Human betaherpe...
ACM48120     432 ---VVGTDAaaaaaaaptvmVGPtamagpaasgtvpramLV-VVLDELGAVFGY-Cp-lDG------------HVYPLAA 493
XP_002596897 216 ---VIGYLQ-----------DDA----------------VV-MVGTQSGKVYLD-K---DE------------IVYNVAD 248
ADD39097      79 ---PFGFVE------------GPgfm----------ryqLI-VLIGQRGGVYCY-Dd-lRD------------CVYELAP 118
ACM48019     116 ---LIGTVS-----------HATcr---------------yqVFVDAYGAVFAY-Da-qED------------CLYELAS 152
P16767       232 yhqLLGALGh----------EVPerke---------flvRQyVLVDTFGVVYGY-Dp-aMD------------AVYRLAE 278 Human herpesvir...
ACM48031     326 ---VVRAVP------------VEsqq----------rldIS-ILVNESGAVFGV-Hp-eTR------------QAHFLAR 365
AKI14898     274 ---VVGLVG-----------YYLaygp--------fvpsGL-VLLDKFGVVYLH-Ki-eDS------------DLYRIAD 316
ADD39174     251 ---LLGAVG-----------SYRaggf--------fdtsFL-IIFDRFCRFYVV-Iv-kSHldrspplqrlagEIYRLAD 305
F5H991       273 ---IMGVVG-----------ESLpsgv--------fhadFV-ILVDRACEFFYF-Dv-sRR------------EIWRLAD 315 Human herpesvir...
AMJ53521     272 ---VLGVTGr----------PRPgrsf---------vaeVL-VLLDWFGAVYAIqMddpNH------------YVRRVAN 316 Human betaherpe...
ACM48120     494 ELSHFLR-AGVLGALALG 510
XP_002596897 249 TLSDFAD-QGCPQNPTFF 265
ADD39097     119 TMKDFLR-HGFRHCDHFH 135
ACM48019     153 DLAGFFA-KGMIRCDPVH 169
P16767       279 DVVMFTCvMGKKGHRNHR 296 Human herpesvirus 5 strain AD169
ACM48031     366 GLLGFFR-VGFLRFCNNY 382
AKI14898     317 NFHMFLK-CGLLKLRGLC 333
ADD39174     306 SLEELFR-AGLMKVYVRR 322
F5H991       316 SVDMLLT-VGLLKIYQAG 332 Human herpesvirus 5 strain Merlin
AMJ53521     317 TITEFFR-MGLLKMVFRH 333 Human betaherpesvirus 5
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap