1X9Y


Conserved Protein Domain Family
Staphopain_pro
?
pfam14731: Staphopain_pro 
Click on image for an interactive view with Cn3D
Staphopain proregion
This domain is the proregion of the cysteine protease staphopain. Like many papain type peptidases, staphopain is synthesized as an inactive precursor and cleavage of the proregion is required for activation. This proregion has a half-barrel or barrel-sandwich hybrid fold. The proregion blocks the active site cleft of the mature enzyme on one side of the nucleophilic cysteine
Links
?
Statistics
?
PSSM-Id: 291401
Aligned: 4 rows
Threshold Bit Score: 240.262
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
1X9Y_A   7 KQLEINVKSDKVPQKVKDLAQQQFAGYAKALDKQSNAKTGKYELGEAFKIYKFNGEEDNSYYYPVI-KDGKIVYTLTLSP 85 
Q2FZL3  41 KQLEINVKSDKVPQKVKDLAQQQFAGYAKALDKQSNAKTGKYELGEAFKIYKFNGEEDNSYYYPVI-KDGKIVYTLTLSP 119 Staphylococcus aureus...
Q2G2R8  37 KHVQVNVEDKSVPTDVRNLAQKDYLSYVTSLDKIYNKEKASYTLGEPFKIYKFNKKSDGNYYFPVLnTEGNIDYIVTISP 116 Staphylococcus aureus...
Q5HKF6  42 KTTKVTVSNKDVPDAVRKLAEEQYLSRVALLDKASNHKATSYTLGEPFKIYKFNKESDGNYYYPVLnKKGDVVYVVTISP 121 Staphylococcus epider...

1X9Y_A  86 KNKDDlNKSKEDMNYSVKISNFIAKDLDQIKDKnsNITVLTDEKGFY-FEEDGKVRLVKATPLANNIKEKESAKTVSPQL 164
Q2FZL3 120 KNKDDlNKSKEDMNYSVKISNFIAKDLDQIKDKnsNITVLTDEKGFY-FEEDGKVRLVKATPLPGNVKEKESAKTVSAKL 198 Staphylococcus aureus...
Q2G2R8 117 KIT---KYSSSSSKYTINVSPFLSKVLNQYKDQ--QITILTNSKGYYvVTQNHKAKLVLKTPRLEDKKLKKTESIPTGNN 191 Staphylococcus aureus...
Q5HKF6 122 NPSNS-KASKQQNNYSINVSPFLSKILNQYKNQ--KITILTNTKGYFaLTEDGKVTLVLKTPRNNEKTYENATESTKPKD 198 Staphylococcus epider...

1X9Y_A 165 KQELKTTVTPTK 176
Q2FZL3 199 KQELKNTVTPTK 210 Staphylococcus aureus subsp. aureus NCTC 8325
Q2G2R8 192 VTQLKQKASVTM 203 Staphylococcus aureus subsp. aureus NCTC 8325
Q5HKF6 199 LNDFKQTASVTK 210 Staphylococcus epidermidis RP62A
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap