Conserved Protein Domain Family
VWD

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smart00216: VWD 
von Willebrand factor (vWF) type D domain
Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.
Statistics
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PSSM-Id: 214566
Aligned: 56 rows
Threshold Bit Score: 82.0645
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O02024        1530 SKLYQTEQPqaTAVIDGN--KATTFSNRTYPId-LGNCYHVF-AMYapqgqG-ENR-QhesSISNIQQGYAVL--VKe-t 1600  bean bug
O18758         120 YSETDAIIg--EASTWGKg-AYKAFNGRVFSF--ESSCSYTF-CRH-----C-VESg---gDFNVEIKRNND-------- 176   domestic pig
P79927         161 PASPEENGStgECGTWGQg-TYKTLHGQMFHC--KSKSTISF-CRH-----C-GDNa----EFNVETKRKE--------- 217   African cla...
A57534         206 GCCHHYQCQc-VCSGWGDp-HYITFDGTYYTF--LDNCTYVL-VQQ-----IvPVY-G---HFRVLVDNYFCGaeDG--- 268   human
Q02817        4470 GCCWHWECDc-yCTGWGDp-HYVTFDGLYYSY--QGNCTYVL-VEE-----I-SPSvD---NFGVYIDNYHCD--PNd-k 4532  human
AAC51344       285 PCDFHYECEc-ICSMWGGs-HYSTFDGTSYTF--RGNCTYVL-MRE-----I-HARfG---NLSLYLDNHYCT--AS--- 345   human
P17554         310 ETCAAPETRg-TCVLSGHt-FYDTFDKARYQF--QGPCKEILmAAD-----C-Y-W-N---TWDVKVSHRDVE--SY--- 369   sea firefly
P17554          70 KTCCRMCQYviECRVEAAg-YFRTFYGKRFNF--QEPGKYVL-ARG-------TKG-G---DWSVTLTMENLD--GQk-- 130   sea firefly
NP_001104817  1941 QCVLPADCLdcTCTGVGTpaKYTTFEGDDLPF--LGNCTYLA-SRDr----N-QTG-Eh--KYQVYATNGPCD--DNa-n 2006  domestic si...
AAA18431       297 GCCITTSAS--VCAAAGV--TPTTSPSTAPTTpsWTTARTLG-AADc----A-RVW-Pl--PRARRQLLLRCG--GRall 361   human
O02024        1601 DS-----EHKEVKVILGSDVIELK------S-Ks---sGLSIQAN----GQn---IHASEKQLTKwsnnnnYL-EAYAr- 1656  bean bug
O18758         177 -S-----EIEKITVIIDNNDISIS---------------GDVILV----NG----ESVHIPYNNK------LI-HIKKy- 219   domestic pig
P79927         218 EG-----HFEKLRFQIDGVEVEAN------D-------NDEIYIN----NKk----ISNEQYNDK------QV-RLRRng 264   African cla...
A57534         269 LS-----CPRSIILEYHQDRVVLTr-----K-P-----VHGVMTNeiifNNk---VVSPAFRKNG------IV-VSRIg- 321   human
Q02817        4533 VS-----CPRTLIVRHETQEVLIK------T-VhmmpmQVQVQVN----RQa---VALPYKKYGL------EV-YQ-Sg- 4584  human
AAC51344       346 ATaaaarCPRALSIHYKSMDIVLTvtmvhgK-E-----EGLILFD----QIp---VSSGFSKNGV------LV-SVLGt- 404   human
P17554         370 -T-----EVEKVTIRKQSTVVDLI------V-D-----GKQVKVG----GVd---VSIPYSSENT------SI-YWQDg- 416   sea firefly
P17554         131 GA-----VLTKTTLEVAGDVIDIT------QaT-----ADPITVN----GGadpvIANPFTIGEV------TIaVVEIp- 183   sea firefly
NP_001104817  2007 IV-----CTKIVHLIYEKNVIHIS------K-Dp---tTKKLRTV----IGktavFKYPVKENWG------TI-SLLNg- 2059  domestic si...
AAA18431       362 PE-----VHHPGVPPGPRGADPQA------S-Pr----GVDKRDH----LQqq--gGQPRLPKNG------IV-VSRIg- 411   human
O02024        1657 PDAVVLSLPQQgiELTYDGAR--VQLSAS-S--SYKGNVRGLAGTFDGQEANDFTTPNN 1710  bean bug
O18758         220 GEHNVLNSRRGilSLMWDKNNk-LSLTIH-----KQYPTCGLCGNFNNTPGEDIDEHIA 272   domestic pig
P79927         265 IYMQFYNHQEDv-KVTWHKNQ--FSLMLN-----KAYETCGLCGGSKDNTDDKTFFESQ 315   African clawed frog
A57534         322 VKMYATIPELGv-QVMFSGLI--FSVEVPfS--KFANNTEGQCGTCTNDRKDECRTPRG 375   human
Q02817        4585 INYVVDIPELGv-LVSYNGLS--FSVRLP-Yh-RFGNNTKGQCGTCTNTTSDDCILPSG 4638  human
AAC51344       405 TTMAVDIPALGv-SVTFNGQV--FQARLPyS--LFHNNTEGQCGTCTNNQRDDCLQRDG 458   human
P17554         417 DILTTAILPEAl-VVKFNFKQl-LVVHIR-D--PFDGKTCGICGNYNQDSTDDFFDAEG 470   sea firefly
P17554         184 GFNITVIEFFKl-IVI-DILGg-RSVRIA-PdtANKGLISGICGNlemndaddfttdad 238   sea firefly
NP_001104817  2060 QDVSVTLPDIHv-ELTVSQLNleFAVRVP-Tf-LYGNRTEGLCGVCAGYQ-DFLVTSNG 2114  domestic silkworm
AAA18431       412 VKMYATIPELGv-QVMFSGLI--FSVEVP-Fs-KFANNTEGQCGTCTNDRKDECRTPRG 465   human
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