TABLE 31

All-cause mortality at 6 and 12 months by treatment arm

OutcomeStandard care arm (n = 805)Intervention arm (n = 799)Overall (n = 1604)p-value
Estimated mortality rate at 6 months from admission,a % (95% CI)27.3 (24.3 to 30.7)26.1 (23.2 to 29.4)26.7 (24.6 to 29.1)
Hazard ratiob (95% CI)0.96 (0.79 to 1.17)0.6748
Hazard ratio also adjusted for participant factorsc (95% CI)1.08 (0.89 to 1.32)
Estimated mortality rate at 12 months from admission,a % (95% CI)27.7 (24.6 to 31.1)26.6 (23.6 to 30.0)27.2 (25.0 to 29.5)
Hazard ratiob (95% CI)0.96 (0.79 to 1.17)0.7120
Hazard ratio also adjusted for participant factorsc (95% CI)1.09 (0.90 to 1.32)
Participants with missing survival data at all time points, n/N (%)10/805 (1)15/799 (2)25/1604 (2)
a

Unadjusted Kaplan–Meier estimate.

b

Intervention arm relative to standard care arm, adjusted for centre; p-value for treatment term in Cox regression model.

c

Intervention arm relative to standard care arm adjusted for centre and significant participant factors.

Note

Participants for whom vital status was not available were not included in this analysis. No participants were excluded for other reasons.

From: Appendix 2, Additional tables and figures

Cover of Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis
Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis.
Health Technology Assessment, No. 28.76.
Curry N, Davenport R, Thomas H, et al.
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