TABLE 29

Quality of life at discharge and 6 months after admission

OutcomeAt discharge or day 28 where aliveAt 6-month follow-up
Standard care arm (n = 805)Intervention arm (n = 799)Overall (n = 1604)p-valueStandard care arm (n = 805)Intervention arm (n = 799)Overall (n = 1604)p-value
Participants who completed EQ-5D-5L index value questions, n/N (%)347/571 (61)324/569 (57)671/1140 (59)47/455 (10)52/468 (11)99/923 (11)
Participants who completed EQ-5D-5L ‘health today’ question, n/N (%)322/571 (56)306/569 (54)628/1140 (55)46/455 (10)51/468 (11)97/923 (11)
Median (IQR) index valuea0.50 (0.20–0.73)0.51 (0.26–0.72)0.50 (0.22–0.73)0.80240.66 (0.36–0.78)0.76 (0.63–0.93)0.70 (0.41–0.86)N/A
Cohen’s d for index value (95% CI)0.01 (−0.14 to 0.17)0.47 (0.07 to 0.87)
Median (IQR) self-evaluated health scorea60 (40–70)50 (30–70)53 (35–70)0.101565 (50–75)75 (51–85)70 (50–80)N/A
Cohen’s d for self-evaluated health score (95% CI)−0.13 (−0.29 to 0.03)0.31 (−0.09 to 0.70)
Participants who completed GOS questionnaire at discharge n/N (%)712/805 (88)705/799 (88)1417/1604 (88)
GOS at discharge, n/N (%) b
Low disability221/712 (31)226/705 (32)447/1417 (32)0.5540
Moderate disability129/712 (18)129/705 (18)258/1417 (18)
Severe disability153/712 (21)155/705 (22)308/1417 (22)
Persistent vegetative state27/712 (4)21/705 (3)48/1417 (3)
Death182/712 (26)174/705 (25)356/1417 (25)
a

p-value for Mann–Whitney test.

b

p-value for ordinal regression, adjusted for centre.

Note

Mann–Whitney tests were not conducted on the 6-month follow-up data due to the very low data completeness for these outcomes.

From: Appendix 2, Additional tables and figures

Cover of Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis
Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis.
Health Technology Assessment, No. 28.76.
Curry N, Davenport R, Thomas H, et al.
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