TABLE 23

All-cause mortality at 28 days by treatment arm: UK participants vs. US participants

OutcomeUK participantsUSA participants
Standard care arm (n = 780)Intervention arm (n = 775)Standard care arm (n = 25)Intervention arm (n = 24)
Participants who died on or before day 28 from admission, n/N (%)198/748 (26.5)187/737 (25.4)3/23 (13.0)5/23 (21.7)
Relative riska (95% CI)0.96 (0.81 to 1.14)1.67 (0.42 to 6.55)
ORa (95% CI)0.95 (0.75 to 1.20)1.85 (0.36 to 9.47)
p-value for subgroup0.63850.4434
p-value for interaction termb0.4092
Participants for whom 28-day vital status was not available from any source, n/N (%)32/780 (4.1)38/775 (4.9)2/25 (8.0)1/24 (4.2)
a

Intervention relative to standard care arm, adjusted for centre.

b

p-value for interaction, adjusted for centre and UK vs. USA.

Note

Participants for whom 28-day vital status was not available were not included in this analysis. No participants were excluded for other reasons.

From: Appendix 2, Additional tables and figures

Cover of Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis
Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis.
Health Technology Assessment, No. 28.76.
Curry N, Davenport R, Thomas H, et al.
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