TABLE 19

Baseline characteristics, by injury type: data are number/total number (%) for categorical variables, and median (IQR) for continuous variables

BluntPenetratingOverall (n = 1604)
Standard care arm (n = 519)Intervention arm (n = 495)Standard care arm (n = 277)Intervention arm (n = 290)
Subjects
Male384/519 (74)355/495 (72)249/277 (90)263/290 (91)1251/1581 (79)
Age (years)46 (30–60)46 (30–60)30 (22–43)30 (22–42)39 (26–55)
Time from injury to admission to emergency department (minutes)88 (67–108)84 (66–106)57 (44–78)59 (41–83)76 (55–100)
Injuries and physiology at admission to emergency department
Blunt injury519/519 (100)495/495 (100)0/277 (0)0/290 (0)1014/1581 (64)
ISS38 (27–50)36 (26–48)18 (11–26)17 (10–26)29 (18–43)
Head AIS ≥ 4176/453 (39)143/437 (33)15/211 (7)14/228 (6)348/1329 (26)
Systolic blood pressure (mmHg)104 (82–128)100 (84–125)102 (84–126)104 (84–124)103 (83–125)
Heart rate (per minute)107 (88–126)108 (89–126)109 (87–129)107 (87–128)108 (88–127)
In cardiac arrest9/479 (2)7/453 (2)8/256 (3)5/264 (2)29/1452 (2)
Glasgow Coma Scale score6 (3–15)12 (3–15)15 (11–15)14 (8–15)14 (3–15)
Pre hospital
RBC (units)0 (0–2)0 (0–2)0 (0–1)0 (0–1)0 (0–2)
FFP (units)0 (0–1)0 (0–1)0 (0–1)0 (0–1)0 (0–1)
Crystalloids (ml)0 (0–250)0 (0–300)0 (0–100)0 (0–100)0 (0–250)
Colloids (ml)0 (0–0)0 (0–0)0 (0–0)0 (0–0)0 (0–0)
TXA administered439/519 (85)406/495 (82)200/277 (72)209/288 (73)1254/1579 (79)

TXA, tranexamic acid.

Note

Summary of missing data: data on all characteristics were missing for 23 participants. In addition, ISS, cardiac arrest and blood pressure were missing for 246, 129 and 119 participants, respectively. There were a small number of missing data for other items.

From: Appendix 2, Additional tables and figures

Cover of Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis
Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis.
Health Technology Assessment, No. 28.76.
Curry N, Davenport R, Thomas H, et al.
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