This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report:

• Julie Bynum, The Geisel School of Medicine at Dartmouth
• Laura Carstensen, Stanford University
• Mark E. Frisse, Vanderbilt University
• Fred Gage, The Salk Institute for Biological Studies
• Adam Gazzaley, University of California, San Francisco
• Charlene Harrington, University of California, San Francisco
• Dilip V. Jeste, University of California, San Diego
• K. Ranga Krishnan, Duke-National University of Singapore Graduate Medical School
• Nancy E. Lane, University of California, Davis, Health System
• Kenneth M. Langa, University of Michigan, Ann Arbor
• Eric B. Larson, Group Health Research Institute
• Sally C. Morton, University of Pittsburgh
• Ruth M. Parker, Emory University
• Ronald C. Petersen, Mayo Clinic
• Brenda Plassman, Duke University School of Medicine
• Thomas R. Prohaska, George Mason University
• George Rebok, Johns Hopkins University

Although the reviewers listed above have provided many constructive comments and suggestions, they did not see the final draft of the report before its release. The review of this report was overseen by Nancy Fugate Woods, Dean Emeritus, University of Washington School of Nursing, and Bradford H. Gray, Editor Emeritus, The Urban Institute. Appointed by the Institute of Medicine, they were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.