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Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.
GPI-anchored protein | Description/ Role |
---|---|
Protozoa | |
Trypanosoma brucei variant surface glycoprotein (VSG) | protective coat |
Leishmania major promastigote surface protease (PSP) | bound complement degradation |
Trypanosoma cruzi GPI-anchored mucins | host cell invasion |
Plasmodium falciparum merozoite surface protein 1 (MSP-1) | erythrocyte invasion |
Toxoplasma gondii surface antigen 1 (SAG-1) | host cell invasion |
Entamoeba histolytica GPI proteophosphoglycans | virulence factor |
Yeast, fungi, slime mold | |
Saccharomyces cerevisiae α-agglutinin | adhesion molecule |
Saccharomyces cerevisiae Gas1 | cell-wall biogenesis |
Aspergillus fumigatus Gel1 | cell-wall biogenesis |
Candida albicans Hwp1 | adhesion molecule |
Dictyostelium discoideum prespore antigen (PsA) | adhesion molecule |
Dictyostelium discoideum contact site A (CsA) | adhesion molecule |
Plants | |
Pyrus arabinogalactan proteins (AGPs) | cell-wall biogenesis |
Arabidopsis thaliana metallo and aspartyl proteases | pollen tube development |
Arabidopsis thaliana β1-3 glucanase | cell-wall biogenesis |
Animals (nonmammalian) | |
Schistosoma mansoni gp200 | praziquantel drug target |
Caenorhabditis elegans odorant response abnormal 2 (ODR-2) | olfaction |
Torpedo marmorata acetylcholinesterase (AchE) | hydrolase |
Mammals | |
Erythrocyte CD59 and decay acceleration factor (DAF) | complement regulation |
Alkaline phosphatase | cell-surface hydrolase |
5′-Nucleotidase | cell-surface hydrolase |
Renal dipeptidase | cell-surface hydrolase |
Trehalase | cell-surface hydrolase |
Neural cell adhesion molecule 120 (NCAM-120)a | adhesion molecule |
Neural cell adhesion molecule TAG-1 | adhesion molecule |
CD58a | adhesion molecule |
FcγIII receptora | Fc receptor |
Ciliary neurotrophic factor receptor (CNTFR) α-subunit | neural receptor |
Glial-cell-derived neurotrophic factor receptor (GDNFR) α-subunit | neural receptor |
CD14 | lipopolysaccharide receptor |
Prion protein (PrP) | unknown |
Glypican family of GPI-anchored proteoglycans | extracellular matrix component |
- Examples of GPI-Anchored Proteins - Essentials of GlycobiologyExamples of GPI-Anchored Proteins - Essentials of Glycobiology
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