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Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.

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Essentials of Glycobiology [Internet]. 4th edition.

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Online Appendix 12AExamples of GPI-Anchored Proteins

, , , , and .

Author Information and Affiliations
GPI-anchored proteinDescription/ Role
Protozoa
Trypanosoma brucei variant surface glycoprotein (VSG)protective coat
Leishmania major promastigote surface protease (PSP)bound complement degradation
Trypanosoma cruzi GPI-anchored mucinshost cell invasion
Plasmodium falciparum merozoite surface protein 1 (MSP-1)erythrocyte invasion
Toxoplasma gondii surface antigen 1 (SAG-1)host cell invasion
Entamoeba histolytica GPI proteophosphoglycansvirulence factor
Yeast, fungi, slime mold
Saccharomyces cerevisiae α-agglutininadhesion molecule
Saccharomyces cerevisiae Gas1cell-wall biogenesis
Aspergillus fumigatus Gel1cell-wall biogenesis
Candida albicans Hwp1adhesion molecule
Dictyostelium discoideum prespore antigen (PsA)adhesion molecule
Dictyostelium discoideum contact site A (CsA)adhesion molecule
Plants
Pyrus arabinogalactan proteins (AGPs)cell-wall biogenesis
Arabidopsis thaliana metallo and aspartyl proteasespollen tube development
Arabidopsis thaliana β1-3 glucanasecell-wall biogenesis
Animals (nonmammalian)
Schistosoma mansoni gp200praziquantel drug target
Caenorhabditis elegans odorant response abnormal 2 (ODR-2)olfaction
Torpedo marmorata acetylcholinesterase (AchE)hydrolase
Mammals
Erythrocyte CD59 and decay acceleration factor (DAF)complement regulation
Alkaline phosphatasecell-surface hydrolase
5′-Nucleotidasecell-surface hydrolase
Renal dipeptidasecell-surface hydrolase
Trehalasecell-surface hydrolase
Neural cell adhesion molecule 120 (NCAM-120)aadhesion molecule
Neural cell adhesion molecule TAG-1adhesion molecule
CD58aadhesion molecule
FcγIII receptoraFc receptor
Ciliary neurotrophic factor receptor (CNTFR) α-subunitneural receptor
Glial-cell-derived neurotrophic factor receptor (GDNFR) α-subunitneural receptor
CD14lipopolysaccharide receptor
Prion protein (PrP)unknown
Glypican family of GPI-anchored proteoglycansextracellular matrix component
a

Examples for which differential mRNA splicing can result in transmembrane and GPI-anchored forms of the same protein.

Copyright © 2022 by the Consortium of Glycobiology Editors, La Jolla, California. Published by Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. All rights reserved.

The content of this book is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported license. To view the terms and conditions of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK579954

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