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Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.

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Figure 1.

Figure 1.

Neuroimaging features of FAHN (A) vs PKAN (B)

The two forms of NBIA share T2-weighted / gradient-echo hypointensity. Distinguishing features include diffuse cerebral atrophy (seen in FAHN) and central globus pallidus T2-weighted hyperintensity (seen in PKAN), producing the characteristic "eye of the tiger" sign.

From: Fatty Acid Hydroxylase-Associated Neurodegeneration

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