Contents

• Clinical guidelines update
• 1. Summary section
  • 1.1. Update information
  • 1.2. Recommendations
  • 1.3. Research recommendations
  • 1.4. Patient-centred care
  • 1.5. Methods
• 2. Evidence review and recommendations
  • 2.1. Epidemiological review
  • 2.2. Review question 1a, 1b and 2
  • 2.3. Review question 3
  • 2.4. Review question 4
  • 2.5. Review question 5
  • 2.6. Review question 6a
  • 2.7. Review question 7a
  • 2.8. Review question 6b and 7b
• 3. References
• 4. Glossary and abbreviations
• Appendices
  • Appendix A. Standing Committee members and NICE teams
  • Appendix B. Declarations of interest
  • Appendix C. Review protocol
  • Appendix D. Search strategy
  • Appendix E. Review flowchart
  • Appendix F. Excluded studies
  • Appendix G. Evidence tables
  • Appendix H. GRADE profiles/Result summary tables
  • Appendix I. Economic search strategy
  • Appendix J. Economic review flowchart
  • Appendix K. Ecomonic excluded studies
  • Appendix L. Economic evidence tables
  • Appendix M. Quality assessment
  • Appendix N. Supporting information
  • Appendix O. Critique of Dayer et al. (2014) study by Ramsay (2015)
  • Appendix P. University of Sheffield’s 2015 update of the 2008 NICE economic model
  • Appendix Q. CG64 original scope

Final

Developed by the National Institute for Health and Care Excellence

Disclaimer: Healthcare professionals are expected to take NICE clinical guidelines fully into account when exercising their clinical judgement. However, the guidance does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of each patient, in consultation with the patient and/or their guardian or carer.