Table 51Exploratory Subgroup Analysis — Acute Coronary Syndrome Patientsa

ParameterStudyTreatmentMonthly rateAlphaBetaStudy duration (months)Distribution
All-cause deathITALIC306- to 12-month DAPT0.000556439618Beta
Extended DAPT0.0012329397
DAPT236- to 12-month DAPT0.000878281,74318
Extended DAPT0.000769251,780
Weighted average6- to 12-month DAPT0.000819
Extended DAPT0.000854
BleedingITALIC306- to 12-month DAPT — all18Beta
6- to 12-month DAPT — major
6- to 12-month DAPT — minor0.0002782
Extended DAPT all
Extended DAPT — major
Extended DAPT — minor0.0005474
DAPT236- to 12-month DAPT — all0.0008713718
6- to 12-month DAPT — major
6- to 12-month DAPT — minor
Extended DAPT all0.00180178
Extended DAPT—major
Extended DAPT — minor
Weighted average6- to 12-month DAPT — all0.000761
Extended DAPT all0.001570
Non-fatal MIITALIC306- to 12-month DAPT0.000972718Beta
Extended DAPT0.0008216
DAPT236- to 12-month DAPT0.0028869218
Extended DAPT0.00123140
Weighted average6- to 12-month DAPT0.002533
Extended DAPT0.001156
Non-fatal strokeDAPT236- to 12-month0.0003761218Beta
Extended DAPT0.00040013
Stent thrombosisDAPT236- to 12-month DAPT0.0010673418Beta
Extended DAPT0.0002779
Urgent revascularizationITALIC306- to 12-month DAPT0.000833618Beta
Extended DAPT0.0000000

DAPT = dual antiplatelet therapy; MI = myocardial infarction.

a

Cohort assumed to have the same average age and gender distribution as full cohort.

From: Appendix 13, Pharmacoeconomics

Cover of Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: Clinical and Economic Impact of Standard Versus Extended Duration
Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: Clinical and Economic Impact of Standard Versus Extended Duration [Internet].
CADTH Optimal Use Report, No. 9.2b.
Wells GA, Elliott J, Kelly S, et al.
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