The objective was to perform a systematic review of the beneficial and harmful effects of ticagrelor 60 mg and 90 mg tablets co-administered with low-dose (75 mg to 150 mg) acetylsalicylic acid, for the prevention of atherothrombotic events in adult patients with a history of myocardial infarction that occurred at least one year ago, and a high risk of developing an atherothrombotic event.

Contents

• Abbreviations
• Executive Summary
• 1. Introduction
  • 1.1. Disease prevalence and incidence
  • 1.2. Standards of therapy
  • 1.3. Drug
• 2. Objectives and Methods
  • 2.1. Objectives
  • 2.2. Methods
• 3. Results
  • 3.1. Findings from the literature
  • 3.2. Included studies
  • 3.3. Patient disposition
  • 3.4. Exposure to study treatments
  • 3.5. Critical appraisal
  • 3.6. Efficacy
  • 3.7. Harms
• 4. Discussion
  • 4.1. Summary of available evidence
  • 4.2. Interpretation of Results
  • 4.3. Potential Place in Therapy
• 5. Conclusions
• APPENDIX 1. Patient Input Summary
• APPENDIX 2. Literature Search Strategy
• APPENDIX 3. Excluded Studies
• APPENDIX 4. Detailed Outcome Data
• APPENDIX 5. Validity of Outcome Measures
• References

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