| Quality assessment | Summary of findings | Quality | Importance | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number | Diagnostic accuracy | True positive | |||||||||||
| No of studies | Design | Risk of bias | Indirectness | Other | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | AUC (95% CI) | Proportion / % | |||
| Definitely abnormal general movements1, assessed by video recording of spontaneous motility in the supine position for at least 5 minutes at corrected age of 3 months| follow up until 3 years 9 months | |||||||||||||
| 1 (Bouwstra 2010) | prosp. cohort | no serious risk of bias | no serious indirectness | none | n = 455 | 67% (13–98) | 97% (94–98) | 12% (2–38) | 100% (99–100) | NR | 3/4552 | HIGH | CRITICAL |
| Neonatal neurological examination adapted from Prechtl 1977 with added predictors3 at term or by latest 5 days after birth. Reference test: Bayley Scale of Infant Development (BSID) (Bayley 1969) | |||||||||||||
| 1 (Wolf, 1997) | prosp cohort | no serious risk of bias | serious4 | none | N = 142 | 73.9 (51.6–89.7) | 98.1 (93.3–99.7) | 89.5 (66.8–98.4) | 94.5 (88.4–97.9) | NR | 23/1425 | MODERATE | CRITICAL |
definitely abnormal general movements characterised by a serious reduction in movement variation and complexity
2 with bilateral spastic CP, 1 with unilateral left-sided spastic CP.
Contains predictors including variation of movement, fixation, fluctuating tone, nasogastric tube feeding, irritability and consolability.
Study conducted in a less resource rich country (Zimbabwe).
16 with quadriplegia, 2 with diplegia, 1 with hemiplegia and 4 with choreoathetosis
From: Appendix H, GRADE Tables
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