| Quality assessment | No of patients | Effect | Quality | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No of study | Design | Limitations | Inconsistency | Indirectness | Imprecision | Other considerations | Non-delayed antibiotic therapy | Delayed antibiotic therapy | Relative (95% CI) | Absolute | |
| Short term mortality: in cancer patients with septic shock 1 | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | serious3 | no serious imprecision | none | 18/20 (90%) | 39/68 (57.4%) | OR 6.5 (1.39 to 30.49) | 324 more per 1000 (from 78 more to 403 more) | VERY LOW |
| Short-term mortality: in patients with bacreremia (67/1523 (4.4%) had ANC < 500 ) | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | serious4 | very serious | strong association | 79/983 (8%) | 50/540 (9.3%) | OR 0.85 (0.59 to 1.24)- | 93 fewer per 1000 (from 93 fewer to 93 fewer) | VERY LOW |
| Short-term mortality: in non-ICU patients with bacteremia and ANC < 100 | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | serious5 | very serious6 | strong association | Not reported | Not reported | OR 18 (2.84 to 113.5) | Not calculable | VERY LOW |
| Short-term mortality: in non-ICU patients with bacteremia and ANC 100-500 | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | very serious5,7 | very serious6 | none | Not reported | Not reported | OR 1.92 (0.17 to 21.6) | Not calculable | VERY LOW |
| Short-term mortality: in non-ICU patients with bacteremia and ANC > 500 | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | very serious5,8 | very serious6 | none | Not reported | Not reported | OR 1.78 (0.91 to 3.45) | Not calculable | VERY LOW |
| Short-term mortality: in ICU patients with bacteremia and ANC < 100 | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | serious5 | very serious6 | none | Not reported | Not reported | OR 5.56 (0.85 to 36.3) | Not calculable | VERY LOW |
| Short-term mortality: in ICU patients with bacteremia and ANC 100-500 | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | very serious5,7 | very serious6 | none | Not reported | Not reported | OR 0.59 (0.06 to 6.22) | Not calculable | VERY LOW |
| Short-term mortality: in ICU patients with bacteremia and ANC > 500 | |||||||||||
| 1 | observational study | serious2 | no serious inconsistency | very serious5,8 | very serious6 | none | Not reported | Not reported | OR 0.55 (0.29 to 1.02) | Not calculable | VERY LOW |
Mortality was not reported by group. These figures were calculated from the overall mortality rate and the odds ratio
Observational study
Cancer patients with septic shock. Very high mortality rate.
Patients with bacteremia (not all neutropenic)
Patients with bacteremia
Very small number of events
Patients with ANC 100-500
From: Initial Treatment: guideline chapter six
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