Table 3.

Potential Prenatal Influences on TID Risk

Pre-natal or intrauterine exposureRelative risk to offspringReference
Maternal ageInconsistent data(44-46)
Birth weight > 2 SD above norm (~4000g)Inconsistent data(47-51)
Birth weight < 2 SD below norm (~2500g)Inconsistent data(49-51)
Birth order: second and later bornsInconsistent data(46, 52, 53)
Birth interval < 3 yearsInconsistent data(46, 54)
Caesarean deliveryInconsistent data(51, 55, 56)
Pre-eclampsiaInconsistent data(51, 57)
Pre-term delivery (<37 weeks gestation)Inconsistent data(51, 58)
Maternal vitamin D supplementationInconsistent data(59-62)
Maternal antibiotic useNo association(53, 63)
maternal BMI/pregnancy weight gainNo association(51, 64)
Maternal omega 3 fatty acid supplementationNo association(60, 65, 66)

From: Changing the Course of Disease in Type 1 Diabetes

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