Figure 9.34. Antibody-coated target cells can be killed by NK cells in antibody-dependent cell-mediated cytotoxicity (ADCC).

Figure 9.34Antibody-coated target cells can be killed by NK cells in antibody-dependent cell-mediated cytotoxicity (ADCC)

NK cells (see Chapter 2) are large granular non-T, non-B lymphoid cells that have FcγRIII (CD16) on their surface. When these cells encounter cells coated with IgG antibody, they rapidly kill the target cell. The importance of ADCC in host defense or tissue damage is still controversial.

From: The destruction of antibody-coated pathogens via Fc receptors

Cover of Immunobiology
Immunobiology: The Immune System in Health and Disease. 5th edition.
Janeway CA Jr, Travers P, Walport M, et al.
New York: Garland Science; 2001.
Copyright © 2001, Garland Science.

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