Large parasites, such as worms, cannot be ingested by phagocytes; however, when the worm is coated with antibody, especially IgE, eosinophils can attack it through their binding to the high-affinity FcεRI. Similar attacks can be mounted by other Fc receptor-bearing cells on various large targets. These cells will release toxic contents of their granules directly onto the target, a process known as exocytosis. Photograph courtesy of A. Butterworth.