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Accession: PRJNA296079 ID: 296079

Homo sapiens (human)

MicroRNA deregulation in laryngeal squamous cell carcinoma cell lines

See Genome Information for Homo sapiens
Cancer of the larynx is the second most common upper-aerodigestive cancer, and laryngeal squamous cell carcinoma (LSCC) is the major histological form. However, the molecular mechanism within LSCC progression remains poorly understood. MicroRNA-based target therapy is a promising approach in cancer therapy and offers multiple advantages as compared with the conventional treatment modalities. Hence, there is a need to identify the key microRNA involved in the progression of LSCC. We used GeneChip miRNA 2.0 array to profile the global microRNA deregulation in LSCC. Overall design: LSCC cell lines (SNU46, SNU899 and SNU1076) and human normal epithelial cultures (HOK1, HOK2 and HTEpiC) derived from head and neck region were selected for RNA extraction. RNA quality was evaluated using Agilent 2100 Bioanalyser. RNA sample with a RIN value over 8 was selected for hybridization on Affymetrix miRNA geneChip 2.0 arrays. MicroRNA with P < 0.05 and 1.5-fold difference were considered as differentiated microRNA in LSCC.
AccessionPRJNA296079; GEO: GSE73171
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsLi JZ et al., "MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma.", Oncotarget, 2016 Sep 6;7(36):58218-58233
SubmissionRegistration date: 18-Sep-2015
Surgery, The University of Hong Kong
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Publications
PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots121488
Data volume, Processed Mbytes4
Data volume, Supplementary Mbytes6

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