Modeling Host Responses to Understand Severe Human... (ID 274402) - BioProject

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Accession: PRJNA274402 ID: 274402

Modeling Host Responses to Understand Severe Human Virus Infections

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

Accession	PRJNA274402; GEO: GSE65575
Type	Umbrella project
Publications (total 3) Less...	Eisfeld AJ et al., "A compendium of multi-omics data illuminating host responses to lethal human virus infections.", Sci Data, 2024 Apr 2;11(1):328 More... Eisfeld AJ et al., "A compendium of multi-omics data illuminating host responses to lethal human virus infections.", Sci Data, 2024 Apr 2;11(1):328 Feng S et al., "Hypergraph models of biological networks to identify genes critical to pathogenic viral response.", BMC Bioinformatics, 2021 May 29;22(1):287 Menachery VD et al., "MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis.", mBio, 2017 Aug 22;8(4) Less...
Grants	"Modeling Host Responses to Understand Severe Human Virus Infections" (Grant ID U19 AI106772, National Institute of Allergy and Infectious Diseases Extramural Activities)
Submission	Registration date: 3-Feb-2015 PNNL
Relevance	Superseries

Project Data:

Resource Name	Number of Links
Publications
PubMed	3
PMC	3
Other datasets
GEO DataSets	60

GEO Data Details

Parameter	Value
Data volume, Spots	74228593
Data volume, Processed Mbytes	1794
Data volume, Supplementary Mbytes	6382

Modeling Host Responses to Understand Severe Human Virus Infections encompasses the following 59 sub-projects:

Project Type

Number of Projects

Transcriptome or Gene expression

BioProject accession	Organism	Title
PRJNA274404	Homo sapiens	Human Calu-3 cell transcriptome response to a wild type infectious clone of Middle Eastern Respiratory Syndrome (icMERS) coronavirus and icMERS mutant viruses (PNNL)
PRJNA274405	Homo sapiens	Immortalized Human Hepatocyte (IHH) transcriptome response to wild-type Ebola viruses Zaire Ebola (ZEBOV '76) and Reston Ebola (REBOV '08) (PNNL)
PRJNA284341	Homo sapiens	Human Calu-3 cell micro RNA transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses (PNNL)
PRJNA284342	Homo sapiens	Human Calu-3 cell transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses (PNNL)
PRJNA287216	Homo sapiens	IHH microRNA response to genetically-reconstructed Zaire Ebola viruses [miRNA] (PNNL)

List all 59 'Transcriptome or Gene expression' projects...

BioProject accession	Organism	Title
PRJNA274404	Homo sapiens	Human Calu-3 cell transcriptome response to a wild type infectious clone of Middle Eastern Respiratory Syndrome (icMERS) coronavirus and icMERS mutant viruses (PNNL)
PRJNA274405	Homo sapiens	Immortalized Human Hepatocyte (IHH) transcriptome response to wild-type Ebola viruses Zaire Ebola (ZEBOV '76) and Reston Ebola (REBOV '08) (PNNL)
PRJNA284341	Homo sapiens	Human Calu-3 cell micro RNA transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses (PNNL)
PRJNA284342	Homo sapiens	Human Calu-3 cell transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses (PNNL)
PRJNA287216	Homo sapiens	IHH microRNA response to genetically-reconstructed Zaire Ebola viruses [miRNA] (PNNL)
PRJNA287217	Homo sapiens	IHH mRNA response to genetically-reconstructed Zaire Ebola viruses [mRNA] (PNNL)
PRJNA287910	Homo sapiens	Human Calu-3 cell transcriptome response to human interferon α [miRNA] (PNNL)
PRJNA287907	Homo sapiens	Human Calu-3 cell transcriptome response to human interferon α [mRNA] (PNNL)
PRJNA292000	Homo sapiens	Immortalized human hepatocyte (IHH) microRNA response to interferon alpha treatment (PNNL)
PRJNA291999	Homo sapiens	Immortalized human hepatocyte (IHH) mRNA response to interferon alpha treatment (PNNL)
PRJNA308120	Homo sapiens	Human Calu-3 cell transcriptome response to a wild type infectious clone of H5N1 Influenza virus and mutant H5N1 viruses [miRNA] (PNNL)
PRJNA308121	Homo sapiens	Human Calu-3 cell transcriptome response to a wild type infectious clone of H5N1 Influenza virus and mutant H5N1 viruses [mRNA] (PNNL)
PRJNA315103	Homo sapiens	Primary human dendritic cell transcriptome response to a wild type MERS-CoV (icMERS) (PNNL)
PRJNA315195	Homo sapiens	Primary human microvascular endothelial cell transcriptome (microRNA) response to wild type MERS-CoV (icMERS-CoV EMC2012) (PNNL)
PRJNA315199	Homo sapiens	Primary human microvascular endothelial cell transcriptome (mRNA) response to a wild type MERS-CoV (icMERS-CoV EMC2012) (PNNL)
PRJNA315871	Homo sapiens	Primary human fibroblast transcriptome (miRNA) response to wild type MERS-CoV (icMERS) (PNNL)
PRJNA315872	Homo sapiens	Primary human fibroblast transcriptome (mRNA) response to wild type MERS-CoV (icMERS) (PNNL)
PRJNA317723	Homo sapiens	Human liver Huh cell transcriptome (miRNA) response to a Wild-type ΔVP30 Ebola virus, Δmucin, and ssGP mutants (PNNL)
PRJNA317724	Homo sapiens	Human liver Huh cell transcriptome (mRNA) response to a Wild-type ΔVP30 Ebola virus, Δmucin, and ssGP mutants (PNNL)
PRJNA319727	Homo sapiens	Human Calu-3 cell transcriptome response to wild-type pandemic H1N1 (A/California/04/2009), natural isolate (PNNL)
PRJNA319728	Homo sapiens	Human Calu-3 cell transcriptome response to wild-type pandemic H1N1 (A/California/04/2009), natural isolate [mRNA] (PNNL)
PRJNA320102	Homo sapiens	Human U937 cell transcriptome response to Zaire Ebola virus wild-type in the ΔVP30 background and Δmucin virus [miRNA] (PNNL)
PRJNA320103	Homo sapiens	Human U937 cell transcriptome response to Zaire Ebola virus wild-type in the ΔVP30 background and Δmucin virus [mRNA] (PNNL)
PRJNA323377	Homo sapiens	Primary human airway epithelial cell transcriptome response to wild type MERS-CoV (icMERS) [mRNA] (PNNL)
PRJNA323378	Homo sapiens	Primary human airway epithelial cell transcriptome response to wild type MERS-CoV (icMERS) [miRNA] (PNNL)
PRJNA342155	Homo sapiens	Primary human fibroblasts transcriptome response to wild type Mers-CoV (icMERS-CoV EMC2012), MFB002 (PNNL)
PRJNA342156	Homo sapiens	Human liver Huh cell transcriptome response to a Wild-type ΔVP30 Ebola virus, EHUH003 [mRNA] (PNNL)
PRJNA342157	Homo sapiens	Primary human Huh (human hepatocyte) cells transcriptome response to wild type Ebola Zaire (delta-VP30), EHUH003 [miRNA] (PNNL)
PRJNA342158	Homo sapiens	Primary human microvascular endothelial cell transcriptome response to wild type Mers-CoV (icMERS-CoV EMC2012), MHAE002 (PNNL)
PRJNA342159	Homo sapiens	Primary human fibroblasts transcriptome response to wild type MERS-CoV (icMERS-CoV EMC2012), MMVE002 (PNNL)
PRJNA391953	Homo sapiens	Primary human fibroblasts transcriptome response to a wild type Mers-CoV (icMERS-CoV), MFB003 (PNNL)
PRJNA391962	Homo sapiens	Primary human airway epithelial cell transcriptome response to a wild type Mers-CoV (icMERS-CoV EMC2012), MHAE003 (PNNL)
PRJNA391978	Homo sapiens	Primary human microvascular endothelial cell transcriptome response to wild type MERS-CoV (icMERS-CoV EMC2012), MMVE003 (PNNL)
PRJNA417084	Homo sapiens	HUH VP30 cells with and without interferon α and β treatment (PNNL)
PRJNA417086	Homo sapiens	Primary human lung fibroblast cells transcriptome response to interferon αβ or interferon γ (PNNL)
PRJNA417087	Homo sapiens	Primary human lung microvascular endothelial cells treated with universal interferon alpha beta or interferon gamma (PNNL)
PRJNA864745	Homo sapiens	HUVEC cell transcriptome response to Zaire Ebola virus (EBOV) and mutant lacking the mucin domain (deltamucin-EBOV) (PNNL)
PRJNA280008	Mus musculus	Mouse cortical neuron transcriptional response to wild-type West Nile virus (WNV-NY) and mutant virus WNV E218A [mRNA] (PNNL)
PRJNA280010	Mus musculus	Mouse cortical neuron transcriptional response to wild-type West Nile virus (WNV NY99 clone 382) and mutant virus WNV E218A [microRNA] (PNNL)
PRJNA282547	Mus musculus	Mouse granule cell neuron transcriptional response to wild-type West Nile virus (WNV-NY) and mutant virus WNV E218A (microRNA) (PNNL)
PRJNA282548	Mus musculus	Mouse granule cell neuron transcriptional response to wild-type West Nile virus (WNV-NY) and mutant virus WNV E218A (mRNA) (PNNL)
PRJNA284146	Mus musculus	Mouse lung tissue transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses [mRNA] (PNNL)
PRJNA284143	Mus musculus	Mouse lung tissue transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses [microRNA] (PNNL)
PRJNA287214	Mus musculus	Mouse lung tissue transcriptome response to H1N1, H5N1, and mutants [mRNA] (PNNL)
PRJNA287215	Mus musculus	Mouse lung tissue transcriptome response to H1N1, H5N1, and mutants [miRNA] (PNNL)
PRJNA292022	Mus musculus	Mouse lung tissue transcriptome response to influenza H5N1 [miRNA] (PNNL)
PRJNA292023	Mus musculus	Mouse lung tissue transcriptome response to influenza H5N1 and mutants [mRNA](Agilent-026655) (PNNL)
PRJNA292712	Mus musculus	Mouse lung tissue transcriptome response to influenza H5N1 and mutants [mRNA](Agilent-028005) (PNNL)
PRJNA294791	Mus musculus	Mouse lung tissue transcriptome response to influenza H5N1 [miRNA] (AmbryGenetics) (PNNL)
PRJNA301036	Mus musculus	Mouse primary myeloid dendritic cell transcriptome response to a wild type infectious clone of West Nile virus (WNVMT) and mutant virus (WNVE218A). (PNNL)
PRJNA302822	Mus musculus	Primary mouse myeloid dendritic cell transcriptome response to a wild type infectious clone of West Nile virus (WNVMT) and mutant virus (WNVE218A). (PNNL)
PRJNA309680	Mus musculus	Mouse cortex transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCT001_miRNA] (PNNL)
PRJNA309681	Mus musculus	Mouse cerebellum transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCB001_microRNA] (PNNL)
PRJNA309682	Mus musculus	Mouse cortex transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCT001_mRNA] (PNNL)
PRJNA309683	Mus musculus	Mouse cerebellum transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [WCB001_mRNA] (PNNL)
PRJNA314302	Mus musculus	Mouse popliteal lymph node transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [mRNA] (PNNL)
PRJNA314303	Mus musculus	Mouse popliteal lymph node transcriptome response to a wild type West Nile virus (WNV), New York 99 Strain, and mutant WNV-E218A viruses [microRNA] (PNNL)
PRJNA382278	Mus musculus	Mouse lung tissue transcriptome response to H1N1 and mutants (PNNL)
PRJNA427769	Mus musculus	Lung cell transcriptome response to a wild type Mers-CoV (PNNL)

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