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3 additional projects are components of the scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection.
Transcriptionally similar subpopulations of exhausted CD8+ T-cells are found in chronic viral infection and tumors
Overall design: RNA-seq analysis of progenitor exhausted and terminally exhausted CD8+ T-cells isolated from spleens of mice chronically infected with LCMV Clone 13 (day 30 post-infection) or isolated from B16-ova tumors (day 22 post tumor implantation), with or without anti-PD-1 treatment
| Accession | PRJNA507854; GEO: GSE123235 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | Miller BC et al., "Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade.", Nat Immunol, 2019 Mar;20(3):326-336 |
| Submission | Registration date: 1-Dec-2018
Haining Lab, Pediatric Oncology, Dana-Farber Cancer Institute |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 54 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 54 |
| GEO DataSets | 1 |