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Accession: PRJNA534492 ID: 534492

Chromatin Loop Extrusion Plays a Fundamental Mechanistic Role in Antibody Class Switching [CSR-HTGTS-Seq] (house mouse)

See Genome Information for Mus musculus
In a B lymphocyte immunoglobulin heavy chain locus (IgH), a developmentally assembled V(D)J exon encoding an antibody variable region lies upstream of exons encoding a  constant region (C), allowing generation of IgH chain transcripts and IgM-class antibodies1. More...
AccessionPRJNA534492; GEO: GSE130265
Data TypeVariation
ScopeMultiisolate
OrganismMus musculus[Taxonomy ID: 10090]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus
PublicationsZhang X et al., "Fundamental roles of chromatin loop extrusion in antibody class switching.", Nature, 2019 Nov;575(7782):385-389
SubmissionRegistration date: 24-Apr-2019
Alt, PCMM, Boston Children's Hospital
RelevanceModel Organism
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments21
Publications
PubMed1
PMC1
Other datasets
BioSample21
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes4
SRA Data Details
ParameterValue
Data volume, Gbases4
Data volume, Mbytes1985

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