See
Genome Information for Schistosoma mansoni
klf4 is enriched in a putative tegument associated lineage of S. mansoni. To characterize cellular and molecular changes associated with klf4 loss of function, we performed single-cell RNAseq on control (RNAi) and klf4 (RNAi) worms
Overall design: Adult male parasites were treated with either klf4-targeting dsRNA or control dsRNA for 17 days before dissociation, then live, single isolated cells were sorted by Fluorescence-activated cell sorting (FACS) and analyzed using scRNAseq.Further data processing was carried out in Seurat (v4.3)
| Accession | PRJNA1114083; GEO: GSE268036 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Schistosoma mansoni[Taxonomy ID: 6183] Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma; Schistosoma mansoni |
| Submission | Registration date: 21-May-2024
Collins lab, Pharmacology, The University of Texas Southwestern Medical Center |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 2 |
| Other datasets |
| BioSample | 2 |
| GEO DataSets | 1 |