8FHD: Cryo-EM structure of human voltage-gated sodium channel Nav1.6

PDB ID: 8FHDDownload
MMDB ID: 226475
PDB Deposition Date: 2022/12/14
Updated in MMDB: 2023/02
Experimental Method:
electron microscopy
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 8FHD: dimeric; determined by author
Molecular Components in 8FHD
Label Count Molecule
Proteins (2 molecules)
1
Sodium Channel Protein Type 8 Subunit Alpha
(Gene symbol: SCN8A)
Molecule annotation
1
Sodium Channel Subunit Beta-1
(Gene symbol: SCN1B)
Molecule annotation
Chemicals and Non-standard biopolymers (35 molecules)
1
11
2-acetamido-2-deoxy-beta-D-glucopyranose (Link to PubChem not yet available)2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranose (Link to PubChem not yet available)beta-D-mannopyranose
3
6
alpha-D-mannopyranose (Link to PubChem not yet available)alpha-D-mannopyranose
4
4
CHOLESTEROL HEMISUCCINATE (Link to PubChem not yet available)CHOLESTEROL HEMISUCCINATE
5
1
CHOLESTEROL (Link to PubChem not yet available)CHOLESTEROL
6
5
1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE (Link to PubChem not yet available)1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE
7
3
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (Link to PubChem not yet available)1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
8
2
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine (Link to PubChem not yet available)O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
9
1
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (Link to PubChem not yet available)(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en
10
1
(5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate (Link to PubChem not yet available)(5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303