7W9M: Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (S6IV pi helix conformer)

PDB ID: 7W9MDownload
MMDB ID: 215822
PDB Deposition Date: 2021/12/10
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 7W9M: trimeric; determined by author
Molecular Components in 7W9M
Label Count Molecule
Proteins (3 molecules)
1
Sodium Channel Protein Type 9 Subunit Alpha
(Gene symbol: SCN9A)
Molecule annotation
1
Sodium Channel Subunit Beta-1
(Gene symbol: SCN1B)
Molecule annotation
1
Sodium Channel Subunit Beta-2
(Gene symbol: SCN2B)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
10
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
(1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name)(1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name)
3
1
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serineO-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
4
5
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
5
1
1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303