7W3Q: Crystal structure of RORgamma in complex with natural inverse agonist

PDB ID: 7W3QDownload
MMDB ID: 224053
PDB Deposition Date: 2021/11/25
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 7W3Q: dimeric; determined by author and by software (PISA)
Molecular Components in 7W3Q
Label Count Molecule
Proteins (2 molecules)
1
Nuclear Receptor Ror-gamma
(Gene symbol: RORC)
Molecule annotation
1
Peptide From Nuclear Receptor Coactivator 2
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-6-methyl-2-oxidanyl-hept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-6-methyl-2-oxidanyl-hept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303