7T8X: Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state

PDB ID: 7T8XDownload
MMDB ID: 225732
PDB Deposition Date: 2021/12/17
Updated in MMDB: 2024/02
Experimental Method:
electron microscopy
Resolution: 3.21  Å
Source Organism:
Mus musculus▼
Similar Structures:
Biological Unit for 7T8X: pentameric; determined by author
Molecular Components in 7T8X
Label Count Molecule
Proteins (5 molecules)
1
Muscarinic Acetylcholine Receptor M2,muscarinic Acetylcholine Receptor M2 Chimera
Molecule annotation
1
Guanine Nucleotide-binding Protein G(o) Subunit Alpha
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Antibody Fragment
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
ACETYLCHOLINEACETYLCHOLINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303