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7ENA: TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)

PDB ID:

7ENA Download

MMDB ID:

202452

PDB Deposition Date:

2021/4/16

Updated in MMDB:

2021/06

Experimental Method:

electron microscopy

Resolution:

4.07 Å

Source Organism:

Sus scrofa▼

Taxonomy	Molecule
Sus scrofa	PA, PB, PC, PD, PE, PF, PG, PH, PI, PJ, PK, PL
Homo sapiens	0, 8, 9, DO, DP, DQ, BA, FA, FB, DA, DB, DD, DE, DF, DG, DH, DI, DJ, DL, Dc, Dd, De, Df, Di, Dj, Dk, Dl, Dm, EA, EB, 1, 2, 3, 4, 5, 6, 7, c, e, b, l, m, a, d, f, g, h, i, j, k, n, o, q, r, s, t, u , v, z, x, w, p, X, Y

Similar Structures:

Biological Unit for 7ENA: 76-meric; determined by author

Molecular Components in 7ENA
Label	Count	Molecule
Proteins (74 molecules)
0	1	Cdk-activating Kinase Assembly Factor Mat1
8	1	Cyclin-dependent Kinase 7
9	1	Cyclin-h
DO	1	Transcription Initiation Factor IIA Subunit 2
DP	1	Tata-box-binding Protein
DQ	1	Tfiia-a
BA	1	Transcription Initiation Factor IIB
FA	1	General Transcription Factor IIF Subunit 1
FB	1	General Transcription Factor IIF Subunit 2
PA	1	Rpb1
PB	1	DNA-directed RNA Polymerase Subunit Beta
PC	1	DNA-directed RNA Polymerase II Subunit Rpb3
PD	1	DNA-directed RNA Polymerase II Subunit Rpb4
PE	1	DNA-directed RNA Polymerase II Subunit E
PF	1	DNA-directed RNA Polymerase II Subunit F
PG	1	DNA-directed RNA Polymerase II Subunit Rpb7
PH	1	DNA-directed RNA Polymerases I, II, and III Subunit Rpabc3
PI	1	DNA-directed RNA Polymerase II Subunit Rpb9
PJ	1	Rpb10
PK	1	RNA_pol_l_2 Domain-containing Protein
PL	1	Rpb12
DA	1	Transcription Initiation Factor Tfiid Subunit 1
DB	1	Transcription Initiation Factor Tfiid Subunit 2
DD Dd	2	Transcription Initiation Factor Tfiid Subunit 4
DE De	2	Transcription Initiation Factor Tfiid Subunit 5
DF Df	2	Transcription Initiation Factor Tfiid Subunit 6
DG	1	Transcription Initiation Factor Tfiid Subunit 7
DH	1	Transcription Initiation Factor Tfiid Subunit 8
DI Di	2	Transcription Initiation Factor Tfiid Subunit 9
DJ Dj	2	Transcription Initiation Factor Tfiid Subunit 10
DL Dl	2	Transcription Initiation Factor Tfiid Subunit 12
Dc	1	Transcription Initiation Factor Tfiid Subunit 3
Dk	1	Transcription Initiation Factor Tfiid Subunit 11
Dm	1	Transcription Initiation Factor Tfiid Subunit 13
EA	1	General Transcription Factor IIE Subunit 1
EB	1	Transcription Initiation Factor IIE Subunit Beta
1	1	General Transcription Factor IIH Subunit 1
2	1	General Transcription Factor IIH Subunit 2
3	1	General Transcription Factor IIH Subunit 3
4	1	General Transcription Factor IIH Subunit 4
5	1	General Transcription Factor IIH Subunit 5
6	1	General Transcription and DNA Repair Factor IIH Helicase Subunit XPB
7	1	General Transcription and DNA Repair Factor IIH Helicase Subunit XPD
c	1	Mediator of RNA Polymerase II Transcription Subunit 27
e	1	Mediator of RNA Polymerase II Transcription Subunit 28
b	1	Mediator of RNA Polymerase II Transcription Subunit 29
l	1	Mediator of RNA Polymerase II Transcription Subunit 30
m	1	Mediator of RNA Polymerase II Transcription Subunit 31
a	1	Mediator of RNA Polymerase II Transcription Subunit 1
d	1	Mediator of RNA Polymerase II Transcription Subunit 4
f	1	Mediator of RNA Polymerase II Transcription Subunit 6
g	1	Mediator of RNA Polymerase II Transcription Subunit 7
h	1	Isoform 2 of Mediator of RNA Polymerase II Transcription Subunit 8
i	1	Mediator of RNA Polymerase II Transcription Subunit 9
j	1	Mediator of RNA Polymerase II Transcription Subunit 10
k	1	Mediator of RNA Polymerase II Transcription Subunit 11
n	1	Mediator of RNA Polymerase II Transcription Subunit 14
o	1	Mediator of RNA Polymerase II Transcription Subunit 15
q	1	Mediator of RNA Polymerase II Transcription Subunit 17
r	1	Mediator of RNA Polymerase II Transcription Subunit 18
s	1	Mediator of RNA Polymerase II Transcription Subunit 19
t	1	Mediator of RNA Polymerase II Transcription Subunit 20
u	1	Mediator of RNA Polymerase II Transcription Subunit 21
v	1	Mediator of RNA Polymerase II Transcription Subunit 22
z	1	Mediator of RNA Polymerase II Transcription Subunit 26
x	1	Mediator of RNA Polymerase II Transcription Subunit 24
w	1	Mediator of RNA Polymerase II Transcription Subunit 23
p	1	Isoform 2 of Mediator of RNA Polymerase II Transcription Subunit 16
Nucleotides(2 molecules)
X	1	DNA (69-mer)
Y	1	DNA(69-mer)
Chemicals and Non-standard biopolymers (18 molecules)
1	16	ZINC ION
2	1	MAGNESIUM ION
3	1	IRON/SULFUR CLUSTER

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303