6UOX: Structure of itraconazole-bound NPC1

PDB ID: 6UOXDownload
MMDB ID: 183223
PDB Deposition Date: 2019/10/15
Updated in MMDB: 2020/01
Experimental Method:
electron microscopy
Resolution: 4.02  Å
Source Organism:
Similar Structures:
Biological Unit for 6UOX: monomeric; determined by author
Molecular Components in 6UOX
Label Count Molecule
Protein (1 molecule)
1
NPC Intracellular Cholesterol Transporter 1
(Gene symbol: NPC1)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
12
N-ACETYL-D-GLUCOSAMINEN-ACETYL-D-GLUCOSAMINE
2
1
ALPHA-D-MANNOSEALPHA-D-MANNOSE
3
1
4-(3-bromo-4-{4-[4-({(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}phenyl)-2-[(2S)-butan-2-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one4-(3-bromo-4-{4-[4-({(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}phenyl)-2-[(2S)-butan-2-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303